Biomolecule diagnostic devices
First Claim
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1. A biosensor, comprising:
- a substrate member defining a surface;
a photo-reactive agent overlying the surface of said substrate member;
a receptive material layer applied directly over said photo-reactive agent and generally uniformly covering said surface of said substrate member, said receptive material being specific for an analyte of interest;
wherein a pattern of active and inactive areas is defined by said receptive material layer, said active and inactive areas formed by a masking process wherein a mask is placed over said substrate member prior to irradiating said substrate member with an energy source sufficient for activating said photo-reactive agent such that areas exposed by said mask define said pattern of inactive areas of said receptive material and said areas shielded by said mask define said pattern of active areas of receptive material; and
wherein said biosensor is configured to detect the presence of an analyte of interest when exposed to a medium containing said analyte of interest by binding the analyte to said receptive material in said active areas and subsequently facilitate diffraction of transmitted light or reflected light in a diffraction pattern corresponding to said active areas.
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Abstract
A biosensor includes a substrate with a layer of receptive material disposed thereon overlying a layer containing a photo-reactive agent. The receptive material is specific for an analyte of interest. A pattern of active and inactive areas of the receptive material are defined in the receptive material layer by a masking process wherein the photo-reactive agent is activated in the exposed regions of the mask.
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Citations
20 Claims
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1. A biosensor, comprising:
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a substrate member defining a surface; a photo-reactive agent overlying the surface of said substrate member; a receptive material layer applied directly over said photo-reactive agent and generally uniformly covering said surface of said substrate member, said receptive material being specific for an analyte of interest; wherein a pattern of active and inactive areas is defined by said receptive material layer, said active and inactive areas formed by a masking process wherein a mask is placed over said substrate member prior to irradiating said substrate member with an energy source sufficient for activating said photo-reactive agent such that areas exposed by said mask define said pattern of inactive areas of said receptive material and said areas shielded by said mask define said pattern of active areas of receptive material; and wherein said biosensor is configured to detect the presence of an analyte of interest when exposed to a medium containing said analyte of interest by binding the analyte to said receptive material in said active areas and subsequently facilitate diffraction of transmitted light or reflected light in a diffraction pattern corresponding to said active areas. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A biosensor, comprising:
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a substrate member defining a surface; a photo-reactive agent overlying the surface of the substrate member; a receptive material layer molecularly attached to the photo-reactive agent, the receptive material being specific for an analyte of interest;
wherein the receptive material layer defines active areas and inactive areas;
wherein the active areas are configured to bind to an analyte of interest, and wherein the inactive areas comprise activated photo-reactive agent and denatured receptive material such that the denatured receptive material does not bind to the analyte of interest;wherein the biosensor is configured to detect the presence of an analyte of interest in a medium through diffraction of transmitted light or reflected light. - View Dependent Claims (15, 16, 17, 18, 19, 20)
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Specification