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Prodrug compounds with isoleucine

  • US 7,696,313 B2
  • Filed: 01/16/2008
  • Issued: 04/13/2010
  • Est. Priority Date: 06/14/2000
  • Status: Expired due to Fees
First Claim
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1. In a method of making a prodrug, a method of removing free therapeutic agent comprising:

  • (1) coupling an optionally protected stabilizing group-oligopeptide conjugate with the free therapeutic agent,(2) contacting the product of step (1) with a polymeric resin to bind free therapeutic agent remaining after step (1) and to form a therapeutic agent-polymeric resin complex, wherein the polymeric resin is polystyrene methylisocyanate, or polystyrene sulfonyl chloride, and(3) removing the therapeutic agent-polymeric resin complex.

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