Apparatus and method for cone beam computed tomography breast imaging

• US 7,697,660 B2
• Filed: 11/17/2005
• Issued: 04/13/2010
• Est. Priority Date: 11/18/1999
• Status: Expired due to Term

• Current Assignee: University of Rochester
• Original Assignee: University of Rochester
• Inventors: Ning, Ruola
• Primary Examiner(s): THOMAS, COURTNEY D
• Application Number:
  US11/280,252
• Publication Number:
  US 20060094950A1
• Time in Patent Office: 1,608 Days
• Field of Search: 378/4, 378/15, 378/19, 378/20, 378/37, 378/98.8, 378/62, 378/901
• US Class Current: 378/37
• CPC Class Codes: A61B 10/0233 Pointed or sharp biopsy instruments
• CPC Class Codes: A61B 2090/3764 with a rotating C-arm having a cone beam emitting source
• CPC Class Codes: A61B 6/027 characterised by the use of a particular data acquisition trajectory, e.g. helical or spiral
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/04 Positioning of patients; Tiltable beds or the like operating tables A61G13/00; operating chairs A61G15/00
• CPC Class Codes: A61B 6/0414 with compression means
• CPC Class Codes: A61B 6/0435 with means for imaging suspended breasts
• CPC Class Codes: A61B 6/06 Diaphragms
• CPC Class Codes: A61B 6/12 Arrangements for detecting or locating foreign bodies
• CPC Class Codes: A61B 6/4085 Cone-beams
• CPC Class Codes: A61B 6/466 adapted to display 3D data
• CPC Class Codes: A61B 6/481 involving the use of contrast agents
• CPC Class Codes: A61B 6/502 for diagnosis of breast, i.e. mammography
• CPC Class Codes: A61B 6/504 for diagnosis of blood vessels, e.g. by angiography
• CPC Class Codes: Y10S 378/901 Computer tomography program or processor

Abstract

Cone beam volume CT breast imaging is performed with a gantry frame on which a cone-beam radiation source and a digital area detector are mounted. The patient rests on an ergonomically designed table with a hole or two holes to allow one breast or two breasts to extend through the table such that the gantry frame surrounds that breast. The breast hole is surrounded by a bowl so that the entire breast can be exposed to the cone beam. Spectral and compensation filters are used to improve the characteristics of the beam. A materials library is used to provide x-ray linear attenuation coefficients for various breast tissues and lesions.

Claims

1. A device for producing an image of a breast of a patient, the device comprising:

a gantry frame;

at least one motor for moving the gantry frame to form a data acquisition geometry in which image data are taken;

a source of a beam of radiation attached to the gantry frame to move with the gantry frame;

a two-dimensional (2D) digital detector attached to the gantry frame to move with the gantry frame, the 2D digital detector being disposed in a path of the beam of radiation;

at least one computer system for controlling a volume scan of the breast, performing reconstruction of the image of the breast and performing image analysis on the image; and

a table on which the patient rests while the image data are taken, the table supporting the patient such that the breast is disposed between the source of cone-beam radiation and the 2D digital detector, the table having a hole through which the breast extends and being configured such that an entirety of the breast extending through the hole is in the path of the beam of radiation;

wherein the at least one motor moves the gantry frame so that the 2D digital detector takes the volume scan of the breast; and

wherein the volume scan of the breast acquires a set of 2D cone beam projection images or multiple sets of 2D cone beam projection images for cone beam tomographic reconstruction, and wherein a three-dimensional cone beam volume CT image is formed from the image signals by performing a cone beam volume CT reconstruction on the cone beam projection images to produce a three-dimensional attenuation coefficient distribution of the breast.

2. The device of claim 1, wherein the table comprises a bowl surrounding the hole and an outer portion at least partially surrounding the bowl, the bowl being depressed relative to the outer portion.

3. The device of claim 2, wherein:

the bowl has a lower surface;

the outer portion has a lower surface; and

the lower surface of the bowl is below the lower surface of the outer portion.

4. The device of claim 3, wherein:

the beam of radiation has an upper extent; and

the upper extent of the beam of radiation substantially coincides with the lower surface of the bowl at the hole.

5. The device of claim 4, wherein:

the source has an uppermost location; and

the uppermost location of the source is higher than the lower surface of the bowl at the hole.

6. The device of claim 5, wherein the uppermost location of the source is lower than the lower surface of the outer portion of the table.

7. The device of claim 5, wherein the uppermost location of the source is higher than the lower surface of the outer portion of the table.

8. The device of claim 2, wherein the table further comprises an intermediate portion between the outer portion and the bowl, the intermediate portion being depressed relative to the outer portion and the bowl being depressed relative to the intermediate portion.

9. The device of claim 1, wherein the source comprises a beam compensation filter for compensating the beam in accordance with a non-uniform thickness of the breast.

10. The device of claim 9, wherein the beam compensation filter has, for each transverse slice, a thickness which is a function of (d_max−

d), where d is a diameter of the breast at said each transverse slice and d_max is a maximum diameter of the breast.

11. The device of claim 10, wherein the function is a linear function.

12. The device of claim 9, wherein the source further comprises a spectrum filter for producing a spectral distribution in the beam.

13. The device of claim 1, wherein the computing device comprises storage for storing a material library comprising x-ray linear attenuation coefficient data for a plurality of breast tissue and lesion types, and wherein the computing device forms the image in accordance with the material library.

14. The device of claim 13, wherein the plurality of breast tissue and lesion types comprise adipose tissue, glandular tissue, base material (e.g. mixture of 50% adipose and 50% glandular), carcinoma and calcification.

43. The device of claim 1, wherein the two-dimensional digital detector is a flat panel detector.

52. The device of claim 1, further comprising a piston for lightly compressing the breast into a cylindrical shape.

53. The device of claim 1, wherein the table is movable between a first, upright position to permit the patient to approach the table in a standing position and a second, horizontal position for taking the volume scan.

54. The device of claim 1, further comprising a wedge for placement on the table adjacent to the breast hole to assist the reposition of patient to assure an appropriate coverage of the patient'"'"'s chest wall and breast.

55. The device of claim 1, wherein the two-dimensional digital detector is a flat panel detector.

56. The device of claim 1, further comprising a slip ring on the gantry frame for providing communication between the 2D digital detector and the computing device and providing power for the x-ray system.

58. The device of claim 1, wherein the at least one motor drives the gantry frame to rotate 360°

for several sets of volume scans of a breast for dynamic studies.

15. A device for producing an image of a breast of a patient, the device comprising:

a gantry frame;

at least one motor for moving the gantry frame to form a data acquisition geometry in which image data are taken;

a source of a beam of radiation attached to the gantry frame to move with the gantry frame, the source comprising a beam compensation filter for compensating the beam in accordance with a non-uniform thickness of the breast;

a two-dimensional (2D) digital detector attached to the gantry frame to move with the gantry frame, the 2D digital detector being disposed in a path of the beam of radiation; and

at least one computer system for controlling a volume scan of the breast, performing reconstruction of the image of the breast and performing image analysis on the image;

wherein the at least one motor moves the gantry frame so that the 2D digital detector takes the volume scan of the breast; and

wherein the volume scan of the breast acquires a set of 2D cone beam projection images or multiple sets of 2D cone beam projection images for cone beam tomographic reconstruction, and wherein a three-dimensional cone beam volume CT image is formed from the image signals by performing a cone beam volume CT reconstruction on the cone beam projection images to produce a three-dimensional attenuation coefficient distribution of the breast.

16. The device of claim 15, wherein the beam compensation filter has, for each transverse slice, a thickness which is a function of (d_max−

d), where d is a diameter of the breast at said each transverse slice and d_max is a maximum diameter of the breast.

17. The device of claim 16, wherein the function is a linear function.

18. The device of claim 15, wherein the source further comprises a spectrum filter for producing a spectral distribution in the beam.

44. The device of claim 15, wherein the two-dimensional digital detector is a flat panel detector.

19. A device for producing an image of a breast of a patient, the device comprising:

a gantry frame;

at least one motor for moving the gantry frame to form a data acquisition geometry in which image data are taken;

a source of a beam of radiation attached to the gantry frame to move with the gantry frame;

a two-dimensional (2D) digital detector attached to the gantry frame to move with the gantry frame, the two-dimensional (2D) digital detector being disposed in a path of the beam of radiation; and

at least one computer, receiving an output from the detector, for forming the image in accordance with the volume scan, the computing device comprising storage for storing a material library comprising attenuation data for a plurality of breast tissue and lesion types, and wherein the computer forms the image in accordance with the material library;

wherein the at least one motor moves the gantry frame so that the two-dimensional (2D) digital detector takes a volume scan of the breast; and

wherein the volume scan of the breast acquires a set of 2D cone beam projection images or multiple sets of 2D cone beam projection images for cone beam tomographic reconstruction, and wherein a three-dimensional cone beam volume CT image is formed from the image signals by performing a cone beam volume CT reconstruction on the cone beam projection images to produce a three-dimensional attenuation coefficient distribution of the breast.

20. The device of claim 19, wherein the plurality of breast tissue and lesion types comprise adipose tissue, glandular tissue, base material (e.g. mixture of 50% adipose and 50% glandular), carcinoma and calcification.

21. A method for producing an image of a breast of a patient, the method comprising:

(a) providing a source of a beam of radiation and a two-dimensional (2D) digital detector which is disposed in a path of the beam of radiation;

(b) disposing the breast in the path of the beam of radiation between the source and the detector such that an entirety of the breast is disposed in the path of the beam;

(c) using the source and the detector to obtain a volume scan of the breast, the volume scan resulting in image data; and

(d) forming the image from the image data;

wherein the volume scan of the breast acquires a set of 2D cone beam projection images or multiple sets of 2D cone beam projection images for cone beam tomographic reconstruction, and wherein a three-dimensional cone beam volume CT image is formed from the image data by performing a cone beam volume CT reconstruction on the cone beam projection images to produce a three-dimensional attenuation coefficient distribution of the breast.

22. The method of claim 21, wherein step (b) comprises providing a table on which the patient rests while the image data are taken, the table supporting the patient such that the breast is disposed between the source of cone-beam radiation and the 2D digital detector, the table having a hole through which the breast extends and being configured such that the entirety of the breast extending through the hole is in the path of the beam of radiation.

23. The method of claim 22, wherein the table comprises a bowl surrounding the hole and an outer portion at least partially surrounding the bowl, the bowl being depressed relative to the outer portion.

24. The method of claim 23, wherein:

the bowl has a lower surface;

the outer portion has a lower surface; and

the lower surface of the bowl is below the lower surface of the outer portion.

25. The method of claim 24, wherein:

the beam of radiation has an upper extent; and

the upper extent of the beam of radiation substantially coincides with the lower surface of the bowl at the hole.

26. The method of claim 25, wherein:

the source has an uppermost location; and

the uppermost location of the source is higher than the lower surface of the bowl at the hole.

27. The method of claim 26, wherein the uppermost location of the source is lower than the lower surface of the outer portion of the table.

28. The method of claim 26, wherein the uppermost location of the source is higher than the lower surface of the outer portion of the table.

29. The method of claim 23, wherein the table further comprises an intermediate portion between the outer portion and the bowl, the intermediate portion being depressed relative to the outer portion and the bowl being depressed relative to the intermediate portion.

30. The method of claim 21, wherein the source comprises a beam compensation filter for compensating the beam in accordance with a non-uniform thickness of the breast.

31. The method of claim 30, wherein the beam compensation filter has, for each transverse slice, a thickness which is a function of (d_max−

d), where d is a diameter of the breast at said each transverse slice and d_max is a maximum diameter of the breast.

32. The method of claim 31, wherein the function is a linear function.

33. The method of claim 30, wherein the source further comprises a spectrum filter for producing a spectral distribution in the beam.

34. The method of claim 21, wherein step (d) comprises storing a material library comprising attenuation data for a plurality of breast tissue and lesion types and forming the image in accordance with the material library.

35. The method of claim 34, wherein the plurality of breast tissue and lesion types comprise adipose tissue, glandular tissue, base material (e.g. mixture of 50% adipose and 50% glandular), carcinoma and calcification.

36. The method of claim 21, wherein step (c) is performed using a data acquisition geometry which is selected from the group consisting of circle, circle plus one or more lines, circle plus one or more arcs, 180 degrees plus cone beam angle, and integer times 360 degrees.

45. The method of claim 21, wherein the image is a three-dimensional image.

46. The method of claim 21, wherein the image is a four-dimensional (space plus time) image.

47. The method of claim 21, further comprising, before step (c), injecting a contrast solution into a region of interest in the breast.

48. The method of claim 21, wherein step (d) comprises two-dimensional noise reduction followed by cone-beam reconstruction.

49. The method of claim 48, wherein the two-dimensional noise reduction comprises one of a digital filter and/or a wavelet transform.

50. The method of claim 21, wherein step (d) comprises cone-beam reconstruction followed by three-dimensional noise reduction.

51. The method of claim 50, wherein the three-dimensional noise reduction comprises one of a digital filter and/or a wavelet transform.

57. The method of claim 21, wherein:

step (d) is performed on a computer;

step (a) comprises providing the source and the detector on a gantry frame and providing a slip ring for providing communication between the detector and the computing device and providing power for the x-ray system; and

step (c) comprises rotating the gantry frame.

59. The method of claim 21, wherein step (c) comprises rotating the source and the detector 360°

for several sets of volume scans of a breast for dynamic studies.

60. The method of claim 57, wherein step (c) comprises rotating the gantry frame to acquire a set of circle projections over 180°

plus cone angle.

61. The method of claim 57, wherein step (c) comprises rotating the gantry frame over N×

360°

, where N is a positive integer.

37. A method for producing an image of a breast of a patient, the method comprising:

(a) providing a source of a beam of radiation and a two-dimensional (2D) digital detector which is disposed in a path of the beam of radiation, the source comprising a beam compensation filter for compensating the beam in accordance with a non-uniform thickness of the breast;

(b) disposing the breast in the path of the beam of radiation between the source and the detector such that an entirety of the breast is disposed in the path of the beam;

(c) using the source and the detector to obtain a volume scan of the breast, the volume scan resulting in image data; and

(d) forming the image from the image data;

wherein the volume scan of the breast acquires a set of 2D cone beam projection images or multiple sets of 2D cone beam projection images for cone beam tomographic reconstruction, and wherein a three-dimensional cone beam volume CT image is formed from the image data by performing a cone beam volume CT reconstruction on the cone beam projection images to produce a three-dimensional attenuation coefficient distribution of the breast.

38. The method of claim 37, wherein the beam compensation filter has, for each transverse slice, a thickness which is a function of (d_max−

d), where d is a diameter of the breast at said each transverse slice and d_max is a maximum diameter of the breast.

39. The method of claim 38, wherein the function is a linear function.

40. The method of claim 37, wherein the source further comprises a spectrum filter for producing a spectral distribution in the beam at an effective energy of over 33 keV.

41. A method for producing an image of a breast of a patient, the method comprising:

(a) providing a source of a beam of radiation and a two-dimensional (2D) digital detector which is disposed in a path of the beam of radiation;

(b) disposing the breast in the path of the beam of radiation between the source and the two-dimensional (2D) digital detector such that an entirety of the breast is disposed in the path of the beam;

(c) using the source and the detector to obtain a volume scan of the breast, the volume scan resulting in image data;

(d) storing a material library comprising attenuation data for a plurality of breast tissue and lesion types; and

(e) forming the image from the image data in accordance with the material library;

wherein the volume scan of the breast acquires a set of 2D cone beam projection images or multiple sets of 2D cone beam projection images for cone beam tomographic reconstruction.

42. The method of claim 41, wherein the plurality of breast tissue and lesion types comprise adipose tissue, glandular tissue, base material (e.g. mixture of 50% adipose and 50% glandular), carcinoma and calcification.