Methods for estimating analyte-related signals, microprocessors comprising programming to control performance of the methods, and analyte monitoring devices employing the methods
First Claim
1. A method of employing an analyte monitoring device to measure an analyte amount or concentration in a subject with an analyte monitoring device having first sensor A and second sensor B, said method comprising:
- contacting the first and second sensors with a physiological fluid of a user containing analyte, in which each sensor is in contact with the physiological fluid;
obtaining analyte-related signals from respective first and second sensors, in which each analyte-related signal is related to the amount or concentration of analyte in the subject;
using a microprocessor, obtaining a ratio of signals from the first sensor A relative to the second sensor B for one of interpolation and/or extrapolation calculation of estimated signal values;
providing a series of analyte-related signals obtained by the analyte monitoring device over time, andreplacing an unusable analyte-related signal with an estimated signal by either;
(A) if one or more analyte-related signals previous to the unusable analyte-related signal and one or more analyte-related signals subsequent to the unusable analyte related signal are available, then interpolation is used to estimate the unusable, intervening analyte-related signal;
or(B) if two or more analyte-related signals previous to the unusable analyte-related signal are available, then extrapolation is used to estimate the unusable, subsequent analyte-related signal.
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Abstract
The present invention relates to methods to increase the number of analyte-related signals used to provide analyte measurement values, e.g., when two or more analyte-related signals are used to obtain a single analyte measurement value a “rolling” value based on the two or more signals can be employed. In another aspect, interpolation and/or extrapolation methods are used to estimate unusable, missing or error-associated analyte-related signals. Further, interpolation and extrapolation of values are employed in another aspect of the invention that reduces the incident of failed calibrations. Further, the invention relates to methods, which employ gradients and/or predictive algorithms, to provide an alert related to analyte values exceeding predetermined thresholds. The invention includes the above-described methods, one or more microprocessors programmed to execute the methods, one or more microprocessors programmed to execute the methods and control at least one sensing and/or sampling device, and monitoring systems employing the methods described herein.
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Citations
20 Claims
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1. A method of employing an analyte monitoring device to measure an analyte amount or concentration in a subject with an analyte monitoring device having first sensor A and second sensor B, said method comprising:
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contacting the first and second sensors with a physiological fluid of a user containing analyte, in which each sensor is in contact with the physiological fluid; obtaining analyte-related signals from respective first and second sensors, in which each analyte-related signal is related to the amount or concentration of analyte in the subject; using a microprocessor, obtaining a ratio of signals from the first sensor A relative to the second sensor B for one of interpolation and/or extrapolation calculation of estimated signal values; providing a series of analyte-related signals obtained by the analyte monitoring device over time, and replacing an unusable analyte-related signal with an estimated signal by either; (A) if one or more analyte-related signals previous to the unusable analyte-related signal and one or more analyte-related signals subsequent to the unusable analyte related signal are available, then interpolation is used to estimate the unusable, intervening analyte-related signal;
or(B) if two or more analyte-related signals previous to the unusable analyte-related signal are available, then extrapolation is used to estimate the unusable, subsequent analyte-related signal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification