Focused ultrasound system with adaptive anatomical aperture shaping

• US 7,699,780 B2
• Filed: 08/11/2004
• Issued: 04/20/2010
• Est. Priority Date: 08/11/2004
• Status: Active Grant

• Current Assignee: InSightec Ltd.
• Original Assignee: Insightec-Image-Guided Treatment Limited (InSightec Ltd.)
• Inventors: Vitek, Shuki, Vortman, Kobi
• Primary Examiner(s): Winakur; Eric F
• Assistant Examiner(s): Laryea; Lawrence N
• Application Number:
  US10/916,998
• Publication Number:
  US 20060058671A1
• Time in Patent Office: 2,078 Days
• Field of Search: 600/439, 600/411, 600/412, 600/453, 600/458, 600/549, 600546-545, 600/407, 600378-381, 600/429, 607/27, 607/89, 607/96, 607/115, 601 1- 4
• US Class Current: 600/439
• CPC Class Codes: A61B 2017/00084 Temperature
• CPC Class Codes: A61B 90/04 Protection of tissue around surgical sites against effects of non-mechanical surgery, e.g. laser surgery protection of eyes against laser radiation A61F9/022
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

A method of treating tissue within a body includes directing an ultrasound transducer having a plurality of transducer elements towards target body tissue, and delivering ultrasound energy towards the target tissue from the transducer elements such that an energy intensity at the target tissue is at or above a prescribed treatment level, while an energy intensity at tissue to be protected in the ultrasound energy path of the transducer elements is at or below a prescribed safety level.

Claims

1. A focused ultrasound system, comprising:

an ultrasound transducer device having a plurality of transducer elements;

drive circuitry coupled to the transducer elements; and

a drive signal controller coupled to the drive circuitry, the drive signal controller configured to individually control delivery of acoustic energy from the transducer elements along an ultrasound energy path towards the target tissue such that an energy intensity measured at the target tissue remains at or above a prescribed treatment level, while an energy intensity measured at tissue to be protected in the ultrasound energy delivery path and outside of the target tissue remains at or below a prescribed safety level, wherein the drive signal controller controls one or more of the transducer elements to create a limited energy density at the tissue to be protected in the ultrasound energy path.

2. The system of claim 1, wherein one or both of the prescribed treatment level and prescribed safety level comprise a temperature threshold or a thermal dose threshold.

3. The system of claim 1, wherein the drive signal controller controls one or more of the transducer elements to provide a beam aperture having a size and a shape for protecting the tissue to be protected in the ultrasound energy path.

4. The system of claim 1, wherein the drive signal controller does not activate or deactivates one or more of the transducer elements for protecting the tissue to be protected in the ultrasound energy path while delivering ultrasound energy to the focal volume.

5. The system of claim 1, wherein the drive signal controller causes one or more of the transducer elements to deliver acoustic energy at an energy level that is lower than an acoustic energy level delivered by one or more other of the transducer elements for protecting the tissue to be protected in the ultrasound energy path while delivering ultrasound energy.

6. A method for creating a treatment plan for treating a patient using a focused ultrasound system, the focused ultrasound system comprising a transducer having a plurality of transducer elements, the method comprising:

identifying target tissue to be treated;

identifying tissue to be protected along an ultrasound energy path outside of the target tissue;

estimating energy intensities at the target tissue and the tissue to be protected based at least in part on the relative position between the transducer and the target tissue and the relative position between the transducer and the tissue to be protected;

specifying operational parameters of one or more of the transducer elements to cause the energy intensity delivered to the target tissue to remain above a prescribed treatment threshold while the estimated energy at the tissue to be protected remains below a prescribed safety threshold; and

creating a treatment plan based on the adjusted operational parameters.

7. The method of claim 6, wherein the identifying steps comprise:

obtaining an image of tissue in the ultrasound energy path; and

identifying the target tissue and the tissue to be protected in the image.

8. The method of claim 6, wherein the operational parameters are selected from the group consisting of a phase, an amplitude, a frequency, a power, and a duration of one or more of the transducer elements.

9. A method for treating a patient using a focused ultrasound system, the focused ultrasound system comprising a transducer having a plurality of transducer elements, the method comprising:

identifying target tissue to be treated;

identifying tissue to be protected along an ultrasound energy path outside of the target tissue;

emitting an acoustic wave towards the target tissue;

measuring energy intensities at the target tissue and the tissue to be protected; and

adjusting operational parameters of one or more of the transducer elements directed to the tissue to be protected if the measured energy intensity at the tissue to be protected is above a prescribed safety threshold while maintaining a minimum energy intensity at the target tissue.

10. A method for creating a treatment plan for treating a patient using a focused ultrasound system, the focused ultrasound system comprising a transducer having a plurality of transducer elements, the method comprising:

creating a model representing energies to be delivered to a patient by respective transducer elements of the transducer;

calculating an energy density based on the model at a tissue region along an ultrasound energy path of the transducer elements, the tissue region associated with patient body tissue to be protected from ultrasound energy treatment;

determining whether the calculated energy density at the tissue region to be protected exceeds a prescribed safety threshold;

determining adjustments to operational parameters of one or more of the transducer elements such that the energy density at the tissue region to be protected remains at or below the prescribed safety threshold while maintaining a minimum energy intensity at a target tissue; and

creating a treatment plan based on the model and the adjustments.

11. The method of claim 10, wherein the model comprises a plurality of rays extending from respective representations of surfaces of the respective transducer elements.

12. The method of claim 11, wherein the rays are created at respective resolutions that are comparable to wavelengths of energies output by the respective transducer elements.

13. The method of claim 10, wherein the adjusting comprises reducing one or more respective transducer element energies.

14. The method of claim 10, wherein the prescribed safety threshold comprises a thermal dose threshold or a temperature threshold.

15. The method of claim 10, wherein the prescribed safety threshold comprises a tissue parameter value.

16. A method using a focused ultrasound system, the focused ultrasound system comprising a transducer having a plurality of transducer elements, the method comprising:

directing the ultrasound transducer towards a first region of a subject;

delivering a sub-lethal ultrasound energy from the transducer elements towards the first region;

obtaining an energy density associated with the delivered ultrasound energy at a second region of the subject;

determining whether the energy density at the second region exceeds a prescribed safety threshold; and

reducing the delivered ultrasound energy from one or more of the transducer elements if the determined energy density at the second region is above the prescribed safety threshold while maintaining a minimum energy intensity at the first region.

17. The method of claim 16, wherein the subject comprises a body of a patient.

18. The method of claim 17, wherein the first region comprises a region of target tissue, and the second region comprises a region of tissue to be protected in an ultrasound energy path of the transducer elements outside of the target tissue region.

19. The method of claim 16, wherein the energy density at the second region is determined by obtaining a temperature or a thermal dose at the second region.

20. The method of claim 16 wherein the energy density at the second region is determined by obtaining a measurement of a tissue parameter related to tissue viability at the second region.

21. The method of claim 16, wherein the delivered ultrasound energy is reduced by changing a phase, an amplitude, or both, of a drive signal of the one of the transducer elements.

22. The method of claim 16, wherein the delivered ultrasound energy is reduced by not activating one of the transducer elements.