Method and system for control of osmotic pump device

• US 7,699,834 B2
• Filed: 12/13/2005
• Issued: 04/20/2010
• Est. Priority Date: 11/09/2005
• Status: Expired due to Fees

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Wood, Victoria Y. H., Ishikawa, Muriel Y., Hood, Leroy E., Tegreene, Clarence T., Langer, Robert, Wood, Lowell L. Jr., Jung, Edward K. Y.
• Primary Examiner(s): Mendez; Manuel A
• Application Number:
  US11/302,450
• Publication Number:
  US 20070135800A1
• Time in Patent Office: 1,589 Days
• Field of Search: 604 65- 67, 604/890.1, 604/891.1, 604/892.1, 604140-155, 128/DIG.12, 128/DIG.13
• US Class Current: 604/892.1
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 2205/0266 Shape memory materials
• CPC Class Codes: A61M 2205/0288 Electro-rheological or magneto-rheological materials
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2205/36 related to heating or cooling
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/145 using pressurised reservoirs, e.g. pressurised by means of pistons
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

Embodiments of a system including a remotely controlled osmotic pump device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, an osmotic pump device is placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the osmotic pump device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. In selected embodiments, a magnetic field, an electric field, or electromagnetic control signal may be used.

Claims

1. A method of controlling an osmotic pump device comprising:

generating an electromagnetic control signal including frequency components absorbable by an electromagnetically responsive control element of a remotely controllable valve, the valve configured to adjust the movement of fluid into or out of the osmotic pump device; and

remotely transmitting the electromagnetic control signal to the osmotic pump device in an environment with signal characteristics sufficient to produce mechanical, thermal or chemical activation of the electromagnetically responsive control element in the remotely controllable valve of the osmotic pump device to control the pumping rate of the osmotic pump device.

2. The method of claim 1, including generating and transmitting the electromagnetic control signal with a remote control signal source.

3. The method of claim 1, including generating the electromagnetic control signal from a model-based calculation.

4. The method of claim 1, including generating the electromagnetic control signal from a stored pattern.

5. The method of claim 1, including:

receiving a feedback signal from the environment; and

based at least in part upon the feedback signal, generating an electromagnetic control signal having signal characteristics expected to produce a desired feedback signal.

6. The method of claim 5, wherein receiving a feedback signal from the environment includes receiving a measure of osmolality or pH within at least portion of the environment.

7. The method of claim 5, wherein receiving a feedback signal from the environment includes receiving a measure of temperature or pressure within at least a portion of the environment.

8. The method of claim 5, wherein receiving a feedback signal from the environment includes receiving a measure of the concentration or chemical activity of a chemical within at least a portion of the environment.

9. The method of claim 1, including:

receiving a feedback signal from the osmotic pump device; and

based at least in part upon the feedback signal, generating an electromagnetic control signal having signal characteristics expected to produce a desired feedback signal.

10. The method of claim 9, wherein receiving a feedback signal from the osmotic pump device includes receiving a signal representing a concentration of an osmotic pressure-generating material in an osmotic fluid within the osmotic pump device.

11. The method of claim 1, including:

receiving user input of one or more control parameters; and

based at least in part upon the one or more control parameters, generating an electromagnetic control signal having signal characteristics expected to produce a desired rate of pumping by the osmotic pump device.

12. The method of claim 1, including activating the electromagnetically responsive control element to produce heating or cooling, wherein the heating or cooling modifies the flow rate of fluid through the remotely controllable valve.

13. The method of claim 1, including activating the electromagnetically responsive control element to produce a change in configuration of the electromagnetically responsive control element, wherein the change in configuration modifies the flow rate of fluid through the remotely controllable valve.

14. The method of claim 1, wherein the steps of generating an electromagnetic control signal and of remotely transmitting the electromagnetic control signal to the osmotic pump device are performed according to instructions provided in the form of software, hardware or firmware.

15. The method of claim 1, wherein producing mechanical, thermal or chemical activation of the electromagnetically responsive control element includes producing a change in configuration of the electromagnetically responsive control element.

16. The method of claim 1, wherein generating the electromagnetic control signal includes generating a radio-frequency electromagnetic signal.

17. The method of claim 1, wherein generating the electromagnetic control signal includes generating a microwave electromagnetic signal.

18. The method of claim 1, wherein generating the electromagnetic control signal includes generating an infrared wavelength electromagnetic signal.

19. The method of claim 1, wherein generating the electromagnetic control signal includes generating an optical wavelength electromagnetic signal.

20. The method of claim 1, wherein generating the electromagnetic control signal includes generating an ultraviolet wavelength electromagnetic signal.

21. The method of claim 1, including generating the electromagnetic control signal under software control.

22. The method of claim 1, including generating the electromagnetic control signal with signal characteristics sufficient to produce contraction in at least one dimension of the electromagnetically responsive control element.

23. The method of claim 1, including generating the electromagnetic control signal with signal characteristics sufficient to produce expansion in at least one dimension of the electromagnetically responsive control element.

24. The method of claim 1, including generating the electromagnetic control signal with signal characteristics sufficient to produce a change in temperature of the electromagnetically responsive control element.

25. The method of claim 1, including generating the electromagnetic control signal with signal characteristics sufficient to produce a change in shape, volume, surface area or orientation of the electromagnetically responsive control element.

26. The method of claim 25, including generating the electromagnetic control signal with signal characteristics sufficient to produce a change in shape in an electromagnetically responsive control element including a shape memory material.

27. The method of claim 26, including generating the electromagnetic control signal with signal characteristics sufficient to produce a change in shape in an electromagnetically responsive control element including a shape memory metal.

28. The method of claim 26, including generating the electromagnetic control signal with signal characteristics sufficient to produce a change in shape in an electromagnetically responsive control element including a shape memory polymer.

29. The method of claim 25, including generating the electromagnetic control signal with signal characteristics sufficient to produce a change in shape in an electromagnetically responsive control element including a bimetallic structure.

30. The method of claim 25, including generating the electromagnetic control signal with signal characteristics sufficient to produce a change in shape in an electromagnetically responsive control element including a polymeric material.