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Antibody-based therapeutics with enhanced ADCC activity

  • US 7,700,321 B2
  • Filed: 10/20/2006
  • Issued: 04/20/2010
  • Est. Priority Date: 10/21/2005
  • Status: Active Grant
First Claim
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1. A method of producing a glycosylated monoclonal antibody or Fc fusion protein comprising:

  • (a) providing a monoclonal antibody or Fc fusion protein producing cell;

    (b) culturing the cell in the presence of an amount of kifunensine sufficient to produce a monoclonal antibody or Fc fusion protein having at least 50% Man5-9(GlcNAc)2 N-glycans; and

    (c) recovering the glycosylated antibody or Fc fusion protein.

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