Exendin agonist analogs to treat diabetes
First Claim
1. A method of treating diabetes in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an exendin agonist peptide analog comprising the amino acid sequence of SEQ ID NO:
- 3 or a pharmaceutically acceptable salt thereof;
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Abstract
Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. The methods are also useful for lowering the plasma glucose level, lowering the plasma lipid level, reducing the cardiac risk, reducing the appetite, and reducing the weight of subjects. Pharmaceutical compositions for use in the methods of the invention are also disclosed.
49 Citations
18 Claims
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1. A method of treating diabetes in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an exendin agonist peptide analog comprising the amino acid sequence of SEQ ID NO:
- 3 or a pharmaceutically acceptable salt thereof;
- View Dependent Claims (2, 3, 4, 5, 6)
- 3 or a pharmaceutically acceptable salt thereof;
-
7. A method of treating diabetes in a human in need thereof comprising administering to the human a therapeutically effective amount of an exendin agonist peptide analog comprising the amino acid sequence of SEQ ID NO:
- 5 or a pharmaceutically acceptable salt thereof;
- View Dependent Claims (8, 9, 10, 11)
- 5 or a pharmaceutically acceptable salt thereof;
-
12. A method of treating diabetes in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an exendin agonist peptide analog comprising the amino acid sequence of SEQ ID NO:
- 9;
HGEGTFTSDLSKQLEEEAVRLFI EFLKNGGPSSGAPPPS-NH2 or SEQ ID NO;
10 HGEGTFTSDLSKQLEEEAVRLFPIEWLKNGGPSSGAPPPS-NH2 to treat diabetes in the subject. - View Dependent Claims (13, 14, 15, 16, 17, 18)
- 9;
Specification