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IL-12/p40 binding proteins

  • US 7,700,739 B2
  • Filed: 06/29/2006
  • Issued: 04/20/2010
  • Est. Priority Date: 06/30/2005
  • Status: Active Grant
First Claim
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1. An isolated binding protein comprising an antigen binding domain, said binding protein capable of binding a p40 subunit of IL-12, said antigen binding domain comprising six CDRs:

  • CDR-H1, CDR-H2, CDR-H3, CDR-L1, CDR-L2, and CDR-L3, as defined below;

    CDR-H1. X1-X2-X3-X4-X5-X6-X7 (SEQ ID NO;

         55), wherein;

    X1 is D, K, T, or S;

    X2 is Y, S, or T;

    X3 is Y, V, G, W, S, or F;

    X4 is I, or M;

    X is H, G, E, or V;

    X6 is V, or is not present; and

    X7 is S, or is not present;

    CDR-H2. X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15-X16-X17-X18-X19-X20 (SEQ ID NO;

         56), wherein;

    X1 is H, D, G, W, S, Y or R;

    X2 is I, or F;

    X3 is Y, W, L, S, N, D or G;

    X4 is W, P, H, T, or S;

    X5 is D, G, E, A, or I;

    X6 is D, G, S, T, or N;

    X7 is D, G, S, or P;

    X8 is K, N, S, E, T, or H;

    X9 is Y, T, P, I, or N;

    X10 is Y, N, T, H, K, S, or G;

    X11 is N, or Y;

    X12 is P, N, A, D, or S;

    X13 is S, E, D, or P;

    X14 is L, K, D, T, or Y;

    X15 is K, F, V, M, R, or A;

    X16 is S, K, Q, P, or is not present;

    X17 is D, G, R, or is not present;

    X18 is F, or is not present;

    X19 is Q, or is not present; and

    X20 is D, or is not present;

    CDR-H3. X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13 (SEQ ID NO;

         57), wherein;

    X1 is R, N, or W;

    X2 is G, T, R, P, or H;

    X3 is I, R, F, Y, or Q;

    X4 is R, V, Y, F, or A;

    X5 is S, N, G, A, or R;

    X6 is A, Y, L, F, or M;

    X7 is M, A, D, L, or F;

    X8 is D, M, Y, or W;

    X9 is Y, D, or N;

    X10 is Y, A, or is not present;

    X11 is M, or is not present;

    X12 is D, or is not present; and

    X13 is Y, or is not present;

    CDR-L1. X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15 (SEQ ID NO;

         58)r wherein;

    X1 is K, or R;

    X2 is A;

    X3 is S;

    X4 is Q, or E;

    X5 is S, or N;

    X6 is V, or I;

    X7 is S, G, or D;

    X8 is N, T, or K;

    X9 is D, N, or Y;

    X10 is V, G, or L;

    X11 is A, I, or H;

    X12 is S, or is not present;

    X13 is F, or is not present;

    X14 is M, or is not present; and

    X15 is N, or is not present;

    CDR-L2. X1-X2-X3-X4-X5-X6-X7-X8 (SEQ ID NO;

         59), wherein;

    X1 is Y, or S;

    X2 is A, or T;

    X3 is S, or A;

    X4 is N, H, S, or Q;

    X5 is R, N, or S;

    X6 is Y, Q, or I;

    X7 is T, S, or G; and

    X8 is S, or is not present;

    andCDR-L3. X1-X2-X3-X4-X5-X6-X7-X8-X9 (SEQ ID NO;

         60), wherein;

    X1 is Q;

    X2 is Q;

    X3 is D, Y, or S;

    X4 is Y, N, K, or I;

    X5 is N, T, S, or E;

    X6 is S, Y, V, or W;

    X7 is P;

    X8 is W, F, Y, L, or P; and

    X9 is T, or S.

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