Antibodies to CD83

• US 7,700,740 B2
• Filed: 05/23/2007
• Issued: 04/20/2010
• Est. Priority Date: 11/21/2001
• Status: Expired due to Fees

• Current Assignee: Celltech Group Limited (UCB SA)
• Original Assignee: Celltech Group Limited (UCB SA)
• Inventors: Chen, Yuching, Andrews, Dawn, Garcia-Martinez, Leon Fernando
• Primary Examiner(s): Belyavskyi; Michail A
• Application Number:
  US11/805,841
• Publication Number:
  US 20080299122A1
• Time in Patent Office: 1,063 Days
• Field of Search: None
• US Class Current: 530/387.9
• CPC Class Codes: C07K 16/2803 against the immunoglobulin superfamily
• CPC Class Codes: C07K 2317/50 characterized by immunoglobulin fragments
• CPC Class Codes: C07K 2317/565 Complementarity determining region [CDR]
• CPC Class Codes: C07K 2317/73 Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention provides methods for modulating the immune system using anti-CD83 antibodies that can influence CD83 function.

Claims

1. An isolated multimerized antibody that can bind to a CD83 polypeptide comprising amino acid sequence SEQ ID NO:

97, wherein the multimerized antibody comprises amino acid sequence SEQ ID NO;

86.

2. The antibody designated 95F04 comprising SEQ ID NOs:

86 and 91.

3. An isolated multimerized antibody that can bind to a CD83 polypeptide comprising amino acid sequence SEQ ID NO:

97, wherein the multimerized antibody comprises amino acid sequence SEQ ID NO;

91.

4. An isolated multimerized antibody that can bind to a CD83 polypeptide comprising amino acid sequence SEQ ID NO:

97, wherein the multimerized antibody comprises amino acid sequence SEQ ID NO;

87, SEQ ID NO;

88, SEQ ID NO;

89, SEQ ID NO;

92, SEQ ID NO;

93, and SEQ ID NO;

94.