Methods and apparatus for determining cardiac stimulation sites using hemodynamic data

• US 7,702,392 B2
• Filed: 02/10/2006
• Issued: 04/20/2010
• Est. Priority Date: 09/12/2005
• Status: Active Grant

• Current Assignee: EBR Systems, Inc.
• Original Assignee: EBR Systems, Inc.
• Inventors: Riley, Richard E., Cowan, Mark W., Brisken, Axel F., Echt, Debra S.
• Primary Examiner(s): Getzow; Scott M
• Application Number:
  US11/351,569
• Publication Number:
  US 20070060961A1
• Time in Patent Office: 1,530 Days
• Field of Search: 607 4- 28
• US Class Current: 607/27
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/36564 controlled by blood pressure

Abstract

Methods and apparatus for determining an endocardial implantation site for implanting an electrode, such as a leadless stimulation electrode. An embodiment of one method in accordance with the invention includes delivering sufficient electrical energy for initiation of cardiac activation to a plurality of different test locations at the heart of a patient, and determining hemodynamic responses in reaction to that the stimulus delivered to the different test locations. This method further includes identifying an implantation site for implanting the electrode by selecting at least one of the test locations corresponding to a favorable hemodynamic response.

Claims

1. A method of implanting a stimulation electrode within the heart of a patient, comprising:

(a) positioning the stimulation electrode at a test location in the heart of a patient;

(b) delivering electrical energy to the location;

(c) determining a first acute hemodynamic response in reaction to the electrical energy delivered to the location;

(d) assessing whether the first acute hemodynamic response is satisfactory;

(e) repeating steps (a) through (d) until the first acute hemodynamic response at the test location is satisfactory;

(f) delivering electrical energy to the test location;

(g) determining a second acute hemodynamic response in reaction to the electrical energy delivered to the test location;

(h) determining whether the second acute hemodynamic response is satisfactory;

(i) repeating steps (a) through (h) until the test location that yields a satisfactory second acute hemodynamic response is identified; and

(j) implanting the electrode at the identified site.

2. The method of claim 1 wherein the test locations are in the endocardial aspect of the left ventricle of the heart.

3. The method of claim 1, further comprising pacing the heart by wirelessly transmitting acoustic energy from an acoustic generator located remotely from the heart to the implanted leadless electrode, wherein the implanted leadless electrode converts the acoustic energy to electrical energy and applies the electrical energy to the identified site.

4. The method of claim 1 wherein determining the first and second acute hemodynamic responses comprises measuring pressure within a chamber of the heart.

5. The method of claim 1 wherein determining the first and second acute hemodynamic responses comprises measuring pressure from a first location within the left ventricle chamber of the heart and a second location within the ascending aorta.

6. The method of claim 1 wherein determining the first and second acute hemodynamic responses comprises measuring (a) pressure from a first location within the left ventricle of the heart and a second location within the ascending aorta, and (b) blood volume in the left ventricle.

7. The method of claim 1, wherein the electrical energy is delivered in step (b) using a lead wire.

8. The method of claim 7, wherein the stimulation electrode is leadless, the leadless stimulation electrode has an acoustic transducer configured to convert acoustic energy to electrical energy, the leadless stimulation electrode is configured to deliver the electrical energy converted by the acoustic transducer to the test location, and the delivering of step (f) uses wireless transmission of acoustic energy to the leadless stimulation electrode.

9. The method of claim 8 further comprising:

determining acute hemodynamic responses in reaction to the electrical energy delivered via the lead wire and in reaction to the electrical energy converted by the acoustic transducer and delivered to the test locations; and

identifying the site for implanting the electrode by operating a computer.

10. The method of claim 9 wherein:

determining acute hemodynamic responses comprises ascertaining at least one hemodynamic parameter selected from at least one of a pressure- volume loop, rate of pressure change, ejection fraction, stroke volume, end systolic pressure, blood motion velocity, cardiac wall motion velocity, cardiac wall motion force, and cardiac wall motion timing for the test locations based on the determined hemodynamic responses; and

identifying the site by operating the computer comprises selecting a test location corresponding to a value of the selected hemodynamic parameter.

11. The method of claim 1 wherein determining the first and second acute hemodynamic responses comprises measuring electrical activation timing within the heart.