Systems and methods for selective thermal treatment

• US 7,704,220 B2
• Filed: 01/25/2006
• Issued: 04/27/2010
• Est. Priority Date: 01/25/2005
• Status: Active Grant

• Current Assignee: Thermopeutix Inc.
• Original Assignee: Thermopeutix Inc.
• Inventors: Solar, Ronald J., Lieber, Glen
• Primary Examiner(s): Sirmons; Kevin C
• Assistant Examiner(s): Mehta; Bhisma
• Application Number:
  US11/338,892
• Publication Number:
  US 20060167399A1
• Time in Patent Office: 1,553 Days
• Field of Search: 604/4.01, 604/6.13, 604/6.16, 604/7, 604/8, 604/27, 604/96.01, 604/102.01, 604/102.03, 604/113, 604/114
• US Class Current: 604/4.01
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities
• CPC Class Codes: A61M 1/3613 Reperfusion, e.g. of the coronary vessels, e.g. retroperfusion
• CPC Class Codes: A61M 1/369 Temperature treatment

Abstract

Systems and methods for selective cooling or heating of a target site in the human body include a catheter having a supply elongated element and a delivery elongated element, with inlet and exit ports. Blood is withdrawn from the supply elongated element and cooled or heated in a control unit. The treated blood is sent to the targeted area via delivery elongated element. The supply elongated element can act as an insulator for the treated blood in the delivery elongated element.

Claims

1. A system for providing selective thermal therapy, the system comprising:

a first elongated element having a first lumen therethrough, said first elongated element having a distal end and a proximal end and a length from said distal end to said proximal end;

an exit port located at said distal end of said first elongated element;

an occlusion element positioned on said first elongated element, proximal to said exit port;

a second elongated element having a second lumen therethrough, said second elongated element coaxial to said first elongated element, said second elongated element having a proximal end and a distal end, said distal end of said second elongated element proximal to said distal end of said first elongated element, said distal end of said second elongated element positioned relative to said distal end of said first elongated element such that said distal end of said second elongated element is in proximity to said distal end of said first elongated element so that the second lumen acts as an insulating layer along a majority of said length of said first elongated element when receiving blood from the body;

wherein said second elongated element is insertable into an artery of the body at a peripheral location of the body and adapted to extend to a remote location of the body;

a second port located at said distal end of said second elongated element, said second port proximal to said occlusion element; and

a control unit in fluid communication with said first lumen and said second lumen, said control unit comprising;

a supply blood inlet in fluid communication with said second lumen, said supply blood inlet for receiving blood from the body;

a thermal adjustor in fluid communication with said supply blood inlet, said thermal adjustor configured for changing a temperature of the received blood so as to provide thermally treated blood; and

a delivery blood outlet in fluid communication with said thermal adjustor and in fluid communication with said first lumen, said delivery blood outlet for providing the thermally treated blood to said first lumen.

2. The system of claim 1, wherein said second port comprises multiple ports.

3. The system of claim 1, wherein said occlusion element is an inflatable balloon.

4. The system of claim 1, wherein said occlusion element includes a hydrophilic coating.

5. The system of claim 1, wherein said occlusion element includes a drug coating.

6. The system of claim 1, wherein at least some of said first lumen, said second lumen and said occlusion element are coated with an anti-thrombotic substance.

7. The system of claim 1, further comprising an auxiliary delivery elongated element between said first and second elongated elements and coaxially arranged with respect to said first elongated element, said auxiliary delivery elongated element having a secondary exit port positioned between said exit port and said inlet port.

8. The system of claim 7, wherein said secondary exit port comprises multiple secondary exit ports.

9. The system of claim 7, further comprising a second occlusion element positioned between said secondary exit port and said inlet port.

10. The system of claim 1, wherein said second elongated element is an auxiliary delivery elongated element and said second port is a secondary exit port, said system further comprising a supply elongated element positioned coaxially with respect to said auxiliary delivery elongated element, said supply elongated element having an inlet port.

11. The system of claim 10, wherein said secondary exit port comprises multiple secondary exit ports.

12. The system of claim 10, wherein said inlet port comprises several inlet ports.

13. The system of claim 10, further comprising a second occlusion element positioned between said secondary exit port and said inlet port.

14. The system of claim 1, wherein said control unit includes a pumping mechanism.

15. The system of claim 1, further comprising a physiological sensor positioned at said exit port.

16. The system of claim 15, wherein said physiological sensor is in communication with said control unit, said control unit configured to calculate an output based on data received from said physiological sensor.

17. The system of claim 1, further comprising an inflatable balloon at said distal end of said first elongated element, said inflatable balloon configured to seal said first lumen upon inflation of said inflatable balloon.

18. The system of claim 1, wherein the peripheral location is a femoral artery, a brachial artery, or a radial artery.

19. The system of claim 1, wherein the remote location is a brain.

20. The system of claim 1, wherein said second elongated element is moveable to adjustably position said distal end of said second elongated element relative to said distal end of said first elongated element.

21. A device for providing selective thermal therapy, the device comprising:

a control unit;

a supply elongated element having a supply lumen therethrough for supplying blood to said control unit, said supply elongated element having at least one inlet port at a distal end thereof for receiving the blood;

a delivery elongated element having a delivery lumen therethrough for receiving thermally treated blood from said control unit and delivering the thermally treated blood to a target site in the body, wherein said supply elongated element is positioned coaxial to said delivery elongated element along a majority of a length of said delivery elongated element thereby providing an insulating layer, wherein the thermally treated blood is the supplied blood after a thermal adjustment, wherein the supply lumen acts as the insulating layer when receiving blood from the body, said delivery elongated element having at least one exit port at a distal end thereof for providing the thermally treated blood to the target site, and wherein said supply elongated element, said control unit and said delivery elongated element form a closed system;

wherein said supply elongated element is insertable into an artery of the body at a peripheral location of the body and adapted to extend to a remote location of the body; and

an occlusion element positioned on said delivery elongated element in a location which is proximal to a distal end of said delivery elongated element and distal to a distal end of said supply elongated element.

22. The device of claim 21, wherein at least some of said supply lumen, said delivery lumen and said occlusion element are coated with an anti-thrombotic substance.

23. The device of claim 21, wherein an outer diameter of said delivery elongated element is at least 0.1 mm smaller than an inner diameter of said supply elongated element, thus creating a space between said delivery elongated element and said supply elongated element, wherein said space defines an inlet port.

24. The device of claim 21, wherein said occlusion element is an inflatable balloon.

25. The device of claim 21, wherein said occlusion element includes a hydrophilic coating.

26. The device of claim 21, wherein said occlusion element includes a drug coating.

27. The device of claim 21, further comprising a second occlusion element distal to said exit port.

28. The device of claim 21, further comprising an auxiliary delivery elongated element between said supply and delivery elongated elements and coaxially arranged with respect to said delivery elongated element.

29. The device of claim 28, wherein said auxiliary delivery elongated element includes a secondary exit port.

30. The device of claim 21, further comprising a physiological sensor positioned at a distal end of said device.

31. The device of claim 30 wherein said physiological sensor is in communication with said control unit, said control unit configured to calculate an output based on data received from said physiological sensor.

32. The device of claim 21, further comprising an inflatable balloon at said distal end of said delivery elongated member, said inflatable balloon configured to seal said delivery lumen upon inflation of said inflatable balloon.

33. The device of claim 21, wherein the peripheral location is a femoral artery, a brachial artery, or a radial artery.

34. The device of claim 21, wherein the remote location is a brain.

35. The device of claim 21, wherein said supply elongated element is moveable to adjustably position said distal end of said supply elongated element relative to said distal end of said delivery elongated element.