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Foamable vehicle and pharmaceutical compositions thereof

  • US 7,704,518 B2
  • Filed: 05/09/2006
  • Issued: 04/27/2010
  • Est. Priority Date: 08/04/2003
  • Status: Active Grant
First Claim
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1. A hygroscopic pharmaceutical composition in a pressurized container comprising:

  • a. at least one hygroscopic substance at a sufficient concentration to provide an Aw value of the hygroscopic pharmaceutical composition of less than 0.9, wherein the hygroscopic substance comprises a polyethylene glycol (PEG) or a polyol;

    b. an anti-infective agent;

    c. about 0.01% to about 5% by weight of at least one polymeric agent, wherein the polymeric agent is a gelling agent;

    d. about 0.2% to about 5% by weight of a surface-active agent; and

    e. a liquefied or compressed gas propellant;

    wherein the composition comprises not more than 10% or about 10% water by weight; and

    wherein the composition forms a breakable foam upon dispensing from the pressurized container.

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