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Digital karyotyping

  • US 7,704,687 B2
  • Filed: 11/13/2003
  • Issued: 04/27/2010
  • Est. Priority Date: 11/15/2002
  • Status: Active Grant
First Claim
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1. A method of karyotyping a genome of a test eukaryotic cell, comprising:

  • sequencing a population of pieces of the genome of the test eukaryotic cell to provide nucleotide sequence of said pieces;

    matching, in silico, pieces of the genome to genomic locations using the nucleotide sequence of said pieces;

    counting the pieces within windows of a selected size throughout the genome to determine number of pieces as a function of genomic location, wherein each window comprises a plurality of genomically clustered pieces;

    comparing the number of pieces enumerated within each window for the test eukaryotic cell to the average number of pieces in windows of the selected size throughout the genome to obtain piece densities per window, wherein the piece densities per window represent the karyotype of the genome of the test eukaryotic cell.

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