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Electrosonic cell manipulation device and method of use thereof

  • US 7,704,743 B2
  • Filed: 03/28/2006
  • Issued: 04/27/2010
  • Est. Priority Date: 03/30/2005
  • Status: Active Grant
First Claim
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1. A method of injecting a substance into a living cell having a cell membrane, comprising the steps of:

  • a. placing the substance, the cell and a liquid into a tapering passage; and

    b. applying an energy to the cell sufficient to induce poration of the cell, wherein the step of applying an energy to the cell, comprises applying an acoustic pressure wave to the liquid, thereby inducing sonoporation in the cell wherein the tapering passage includes a narrow end that defines an opening passing therethrough, wherein the method further comprises the step of forcing the cell through the opening so that as the cell passes through the opening the cell membrane allows the substance to pass therethrough.

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