Method of preventing and/or treating oxidant injury in neurodegenerative and oxidative diseases

• US 7,705,054 B1
• Filed: 10/20/2005
• Issued: 04/27/2010
• Est. Priority Date: 10/20/2004
• Status: Active Grant

• Current Assignee: Vanderbilt University
• Original Assignee: Vanderbilt University
• Inventors: Viswanathan, Prakash C., Balser, Jeffrey R., Amarnath, Venkataraman, Roberts, L. Jackson II, Davies, Sean S.
• Primary Examiner(s): Padmanabhan; Sreeni
• Assistant Examiner(s): CLAYTOR, DEIRDRE RENEE
• Application Number:
  US11/254,846
• Time in Patent Office: 1,650 Days
• Field of Search: 514/649, 514/659
• US Class Current: 514/649
• CPC Class Codes: A61K 31/135 having aromatic rings , e.g. ketamine, nortriptyline methadone A61K31/137
• CPC Class Codes: A61K 31/44 Non condensed pyridines; Hydrogenated derivatives thereof

Abstract

A method of treating and/or preventing oxidative damage, comprising administering an effective IsoK/NeuroK adduct formation suppressing amount of a phenolic amine compound and/or pyridoxamine or pyridoxamine analog, including embodiments where the phenolic compound is at least one of a pyridoxamine, salicylamine, tyrosine compound or an analog thereof.

Claims

1. A method of treating and/or reducing the likelihood of progression of oxidative damage contributing to cognitive deficits in deficits in dementia and/or Alzheimer'"'"'s disease, comprising administering an effective IsoK/NeuroK adduct formation suppressing amount of a phenolic amine compound, or a pharmaceutical composition comprising a compound of the following formula:

3. The method of claim 1, wherein the compound is an analog of the following formula:

4. The method of claim 1, wherein the compound is of the following formula:

5. The method of claim 1, wherein the compound is of the following formula:

6. The method of claim 1, wherein the compound is of the following formula:

7. The method of claim 1, wherein the compound is of the following formula:

2. The method of 1, wherein the compound is at least one of a pyridoxamine, salicylamine, tyrosine compound.

8. A method of reducing the likelihood of onset of or retarding the progression of a neurodegenerative disease exasperated by oxidative damage, comprising administering an effective oxidative damage decreasing amount of a phenolic amine compound or a pharmaceutical composition comprising a compound of the following formula:

9. The method of claim 8, wherein the neurodegenerative disease is Alzheimer'"'"'s disease.

10. The method of claim 8, wherein the neurodegenerative disease is dementia.