Apparatus and methods for automatic determination of a fusion pacing pre-excitation interval

• US 7,706,879 B2
• Filed: 04/30/2007
• Issued: 04/27/2010
• Est. Priority Date: 04/30/2007
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Sambelashvili, Aleksandra T., Mullen, Thomas J., Burnes, John E.
• Primary Examiner(s): Manuel; George
• Assistant Examiner(s): Wieland; Robert N
• Application Number:
  US11/742,230
• Publication Number:
  US 20080269823A1
• Time in Patent Office: 1,093 Days
• Field of Search: 607/9, 607/17, 607/25
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

Automated adjustment of a pre-excitation interval (PEI) used to deliver hemodynamically efficient fusion pacing therapy.

Claims

1. A method of determining a pre-excitation interval (PEI) for optimized delivery of a bi-ventricular, fusion-pacing therapy to a non-synchronous pair of ventricles, including delivery of a single ventricular pre-excitation pacing pulse to a relatively late activated ventricular chamber to promote mechanical synchrony between the late activated ventricular chamber and a relatively more rapid, intrinsically-conducting ventricular chamber, comprising:

measuring an intrinsic atrio-ventricular delay interval for a first-to-depolarize ventricular (V1) chamber for at least one prior cardiac cycle;

delivering a pacing stimulus to the V1 chamber upon expiration of an atrio-ventricular (A-V) delay interval and sensing the resulting evoked depolarization in a last-to-depolarize ventricular (V2) chamber, wherein the AV delay interval is shorter than the intrinsic atrio-ventricular delay interval and wherein the; and

calculating a PEI using upon at least one of the following and based upon the relative temporal length of the interval between the V1 pacing stimulus delivery and the V2 sensing of the evoked depolarization;

PEI=k×

(V2p→

V1s) or PEI=k×

(V1p→

V2s) or PEI=k×

(V1s→

V2s), or PEI=k×

[(V1s→

V2s)−

(V2p→

V1s)], and wherein the value of the constant k is about zero-point-five (0.5).

2. A method according to claim 1, further comprising:

delivering during a subsequent cardiac cycle at least one ventricular pre-excitation pacing pulse to the V2 chamber, wherein said at least one ventricular pre-excitation pacing pulse is delivered at the expiration of a V2 pacing interval, wherein the V2 pacing interval is temporally shorter than the intrinsic atrio-ventricular delay interval of the V1 chamber.

3. A method according to claim 1, further comprising:

adjusting the value of the constant, k, based at least in part upon one of a measured patient physiologic parameter and an estimated patient physiologic parameter.

4. A method according to claim 3, wherein the physiologic parameter comprises one of a patient activity metric and a mechanical measurement of left ventricular wall motion.

5. A method of determining the value of an operating pre-excitation interval (PEI) for optimized delivery of a bi-ventricular, fusion-pacing therapy to a non-synchronous pair of ventricles, including delivery of a single ventricular pre-excitation pacing pulse to a relatively late activated ventricular chamber to promote mechanical synchrony between the relatively late activated ventricular chamber and a relatively more rapid, intrinsically-conducting ventricular chamber, comprising:

calculating a PEI value as a linear function of LVp-RVs and RVs-LVs wherein;

PEI=a*(RVs−

LVs)−

b*(LVp−

RVs)+c, where a, b and c are coefficients that can be determined from patient data.

6. A method according to claim 5, wherein the PEI value is adjusted based upon an assessment of one or more of the interventricular conduction times (IVOT) from the relatively late activated ventricular chamber and the relatively more rapid, intrinsically-conducting chamber.

7. A method according to claim 6, wherein a change in the IVCT comprises one of the following:

if (RVs→

LVs>

LVp→

RVs) increases, (RVp→

LVs>

LVp→

RVs) increases, (RVs→

LVs) increases, (RVp→

LVs) increases, or (RVs/p→

LVs) increases more than left ventricular to right ventricular conduction, then performing the following step;

shortening the PEI value to allow more intrinsic activation to spread across the LV.

8. A method according to claim 6, wherein a change in the IVCT comprises one of the following:

if (RVs→

LVs<

LVp→

RVs) increases, (RVp→

LVs<

LVp→

RVs) increases, (LVp→

RVs) increases, or (LVp→

RVs) increases more than the right ventricular to left ventricular conduction time, the performing the followings step;

lengthening the PEI to allow more time for left ventricular paced activation to spread across the left ventricle.

9. A method according to claim 6, further comprising:

making a measurements of the A-RVs-LVs conduction times as part of;

a) a fusion pacing AV interval tests (AVITs), and b) following an extension of the AV interval during AV conduction testing (Aevent-RVsense).

10. A method of determining a pre-excitation interval for optimized delivery of a bi-ventricular, fusion-pacing therapy to a non-synchronous pair of ventricles, including delivery of a single ventricular pre-excitation pacing pulse to a relatively late activated ventricular chamber to promote mechanical synchrony between the late activated ventricular chamber and a relatively more rapid, intrinsically-conducting ventricular chamber, comprising:

measuring an intrinsic atrio-ventricular delay interval for one of the chambers for at least one cardiac cycle;

delivering a pacing stimulus to the one of the chambers upon expiration of a first defined A-V delay shorter than the intrinsic atrio-ventricular delay interval and sensing the resulting evoked depolarization in the other of the chambers; and

calculating a pre-excitation interval based upon length of the interval between the delivered pacing stimulus and the sensed evoked depolarization of wherein the pre-excitation interval equals a constant “

k”

times the interval between the delivered pacing stimulus and the sensed evoked depolarization and wherein k is about 0.5.

11. A method according to claim 10, further comprising:

delivering during a subsequent cardiac cycle at least one ventricular pre-excitation pacing pulse to the relatively late activated ventricular chamber, wherein said at least one ventricular pre-excitation pacing pulse is delivered at the expiration of an interval following a second defined A-V delay equal to the intrinsic atrio-ventricular delay interval minus the pre-excitation interval.

12. A method according to claim 11, further comprising:

adjusting the value of k, based at least in part upon one of a measured patient physiologic parameter and an estimated patient physiologic parameter.

13. A method according to claim 12, wherein the PEI value is adjusted based upon an assessment of one or more of the interventricular conduction times (IVCT) from the relatively late activated ventricular chamber and the relatively more rapid, intrinsically-conducting chamber.

14. A method according to claim 13, wherein a change in the IVCT comprises one of the following:

if (RVs→

LVs>

LVp→

RVs) increases, (RVp→

LVs>

LVp→

RVs) increases, (RVs→

LVs) increases, (RVp→

LVs) increases, or (RVs/p→

LVs) increases more than left ventricular to right ventricular conduction, then performing the following step;

shortening the PEI value to allow more intrinsic activation to spread across the LV.

15. A method according to claim 13, wherein a change in the IVCT comprises one of the following:

if (RVs→

LVs<

LVp→

RVs) increases, (RVp→

LVs<

LVp→

RVs) increases, (LVp→

RVs) increases, or (LVp→

RVs) increases more than the right ventricular to left ventricular conduction time, the performing the followings step;

lengthing the PEI to allow more time for left ventricular paced activation to spread across the left ventricle.

19. A method according to claim 12, wherein the PEI value is adjusted based upon an assessment of one or more of the interventricular conduction times (IVCT) from the relatively late activated ventricular chamber and the relatively more rapid, intrinsically-conducting chamber.

20. A method according to claim 19, wherein a change in the IVCT comprises one of the following:

if (RVs→

LVs>

LVp→

RVs) increases, (RVp→

LVs>

LVp→

RVs) increases, (RVs→

LVs) increases, (RVp→

LVs) increases, or (RVs/p→

LVs) increases more than left ventricular to right ventricular conduction, then performing the following step;

shortening the PEI value to allow more intrinsic activation to spread across the LV.

21. A method according to claim 19, wherein a change in the IVCT comprises one of the following:

if (RVs→

LVs<

LVp→

RVs) increases, (RVp→

LVs<

LVp→

RVs) increases, (LVp→

RVs) increases, or (LVp→

RVs) increases more than the right ventricular to left ventricular conduction time, the performing the followings step;

lengthing the PEI to allow more time for left ventricular paced activation to spread across the left ventricle.

16. A method of determining a pre-excitation interval for optimized delivery of a bi-ventricular, fusion-pacing therapy to a non-synchronous pair of ventricles, including delivery of a single ventricular pre-excitation pacing pulse to a relatively late activated ventricular chamber to promote mechanical synchrony between the late activated ventricular chamber and a relatively more rapid, intrinsically-conducting ventricular chamber, comprising:

measuring an intrinsic inter-ventricular delay interval between the chambers for at least one cardiac cycle; and

calculating a pre-excitation interval based upon length of the measured intrinsic inter-ventricular delay interval wherein the pre-excitation interval equals a constant “

k”

times the interval between the delivered pacing stimulus and the sensed evoked depolarization and wherein k is about 0.5.

17. A method according to claim 16, further comprising:

delivering during a subsequent cardiac cycle at least one ventricular pre-excitation pacing pulse to the relatively late activated ventricular chamber, wherein said at least one ventricular pre-excitation pacing pulse is delivered at the expiration of an interval following a second defined A−

V delay equal to the intrinsic atrio-ventricular delay interval minus the pre-excitation interval.

18. A method according to claim 17, further comprising:

adjusting the value of k, based at least in part upon one of a measured patient physiologic parameter and an estimated patient physiologic parameter.