Baroreflex stimulation synchronized to circadian rhythm
First Claim
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1. A baroreflex stimulator for delivering baroreflex therapy that follows an intrinsic circadian rhythm, including:
- a sensor adapted to sense blood pressure;
a pulse generator operationally connected to the sensor and adapted to deliver a baroreflex stimulation therapy using a baroreflex stimulation signal to provide a target blood pressure;
a circadian rhythm template storage with a circadian rhythm template stored therein, wherein the template reflects the intrinsic cardiac rhythm by reflecting natural fluctuations in a parameter related to hypertension during a day, anda modulator operationally connected to the pulse generator and to the circadian rhythm template storage, the modulator configured to change the target blood pressure to mimic natural blood pressure fluctuations during the day using the circadian rhythm template,wherein the modulator is configured to follow the circadian rhythm template to adjust the target blood pressure to mimic natural blood pressure fluctuations during the day, and the pulse generator uses the sensed blood pressure as feedback for adjusting the baroreflex therapy to provide the target blood pressure, as adjusted by the modulator, to mimic natural blood pressure fluctuations during the day.
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Abstract
An aspect relates to a baroreflex stimulator. An embodiment of the stimulator comprises a pulse generator to provide a baroreflex stimulation signal through an electrode, and a modulator to modulate the baroreflex stimulation signal based on a circadian rhythm template.
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Citations
28 Claims
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1. A baroreflex stimulator for delivering baroreflex therapy that follows an intrinsic circadian rhythm, including:
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a sensor adapted to sense blood pressure; a pulse generator operationally connected to the sensor and adapted to deliver a baroreflex stimulation therapy using a baroreflex stimulation signal to provide a target blood pressure; a circadian rhythm template storage with a circadian rhythm template stored therein, wherein the template reflects the intrinsic cardiac rhythm by reflecting natural fluctuations in a parameter related to hypertension during a day, and a modulator operationally connected to the pulse generator and to the circadian rhythm template storage, the modulator configured to change the target blood pressure to mimic natural blood pressure fluctuations during the day using the circadian rhythm template, wherein the modulator is configured to follow the circadian rhythm template to adjust the target blood pressure to mimic natural blood pressure fluctuations during the day, and the pulse generator uses the sensed blood pressure as feedback for adjusting the baroreflex therapy to provide the target blood pressure, as adjusted by the modulator, to mimic natural blood pressure fluctuations during the day. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A baroreflex stimulator for delivering baroreflex therapy that follows an intrinsic circadian rhythm, comprising:
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a sensor adapted to sense blood pressure; a pulse generator connected to the sensor and adapted to deliver a baroreflex stimulation therapy using a baroreflex stimulation signal to provide a target blood pressure; a circadian rhythm template storage with a circadian rhythm template stored therein, wherein the template reflects the intrinsic cardiac rhythm by reflecting natural fluctuations in a parameter related to hypertension during a day, and means for changing the target blood pressure to follow the circadian rhythm template and mimic natural blood pressure fluctuations during the day. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification