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Methods for upregulating an immune response with agents that inhibit the intereaction between PD-L2 and PD-1

  • US 7,709,214 B2
  • Filed: 06/20/2007
  • Issued: 05/04/2010
  • Est. Priority Date: 06/28/2000
  • Status: Expired due to Fees
First Claim
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1. A method for upregulating an immune response, comprising contacting a PD-L2 polypeptide comprising the amino acid sequence shown in SEQ ID NO:

  • 2 or a cell expressing the polypeptide with a compound which binds to the polypeptide and downmodulates the interaction between the polypeptide and PD-1 in a sufficient concentration to downmodulate PD-1 mediated signaling by the polypeptide such that the immune response is upmodulated, wherein the compound is selected from the group consisting of;

    a blocking antibody that recognizes PD-L2, a combination of a blocking antibody that recognizes PD-L2 and a blocking antibody that recognizes PD-L1, a form of PD-L2 that does not activate PD-1, and a soluble form of PD-1.

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