Systems, methods and apparatus for single molecule sequencing
First Claim
Patent Images
1. A system for analysis of an analyte, the system comprising:
- a substrate;
an exclusion layer deposited on the substrate, the exclusion layer having a hole reaching a portion of the substrate;
a fluid sample contacting the substrate through the hole;
an excitation light source configured to induce an evanescent wave field with a penetration depth that is below a top surface of the exclusion layer, wherein the evanescent wave field energizes a first inorganic absorber bound to the substrate; and
a detector configured to detect light emissions.
6 Assignments
0 Petitions
Accused Products
Abstract
An embodiment generally relates to a system for analysis of an analyte. The system can include a transparent substrate. The system also includes an excitation light source configured to induce an evanescent wave excitation of a fluorescently labeled molecule near the access to the transparent substrate and a detector for detecting the fluorescently labeled molecule.
-
Citations
20 Claims
-
1. A system for analysis of an analyte, the system comprising:
-
a substrate; an exclusion layer deposited on the substrate, the exclusion layer having a hole reaching a portion of the substrate; a fluid sample contacting the substrate through the hole; an excitation light source configured to induce an evanescent wave field with a penetration depth that is below a top surface of the exclusion layer, wherein the evanescent wave field energizes a first inorganic absorber bound to the substrate; and a detector configured to detect light emissions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
-
-
11. A system for analysis of analyte, the system comprising:
-
a transparent substrate coated with a metal layer; an exclusion coating deposited on the metal layer; a fluorescently labeled molecule configured to diffuse into a hole in the exclusion coating; and an excitation light source configured to produce plasmon-coupled emission with a penetration depth that is below a top surface of the exclusion coating. - View Dependent Claims (12, 13, 14)
-
- 15. A luminescence detection system, the system comprising a resonant optical cavity, wherein luminophore emission is elicited by evanescent excitation established within the boundary of the resonant optical cavity.
Specification