Adjusting the maximum ventricular stimulation frequency according to the hemodynamic state of the patient in an active implantable medical device

• US 7,711,422 B2
• Filed: 10/14/2004
• Issued: 05/04/2010
• Est. Priority Date: 10/16/2003
• Status: Active Grant

• Current Assignee: Sorin CRM SAS (MicroPort Scientific Corp.)
• Original Assignee: Ela Medical SAS (MicroPort Scientific Corp.)
• Inventors: Dal Molin, Renzo
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Gedeon; Brian T
• Application Number:
  US10/965,689
• Publication Number:
  US 20050137635A1
• Time in Patent Office: 2,028 Days
• Field of Search: 607 17- 20, 607/24, 600/513, 600/547, 600/510, 600/526
• US Class Current: 607/17
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

Adjusting the maximum ventricular stimulation frequency according to the hemodynamic state of the patient in an active implantable medical device. This device provides for limiting ventricular stimulation to a maximum frequency (F_max), the rate of delivery of the stimulation pulses, measuring an intracardiac bio-impedance (Z_n, Z_n+1), and adjusting the maximum frequency according to the measured intracardiac bio-impedance. The adjusting process can include evaluating a parameter representative of the cardiac flow (d_n, d_n+1) utilizing the intracardiac signal of bio-impedance; controlling a predetermined variation (X %) of the frequency (f) of delivery of the stimulation pulses; evaluating the correlative variation (y %) of the cardiac flow; and adjusting the value of the maximum frequency (F_max) according to the variation of the cardiac flow thus evaluated.

Claims

1. An active implantable medical device, comprising

means for delivering stimulation pulses to at least one site of a cardiac cavity;

means for controlling a delivery frequency of the stimulation pulses;

means for limiting to a maximum frequency the delivery frequency of the stimulation pulses;

means for measuring an intracardiac bio-impedance;

means for adjusting the maximum frequency to a value that is a function of the measured intracardiac bio-impedance;

means for evaluating a parameter representative of cardiac flow based upon a signal delivered by the means for measuring the intracardiac bio-impedance;

means for changing the delivery frequency of the stimulation pulses in a successive cardiac cycle by a programmable variation (X %);

means for measuring a change in the parameter representative of cardiac flow over the successive cardiac cycle;

means for evaluating a first condition, the first condition being that the ratio of the change in the parameter representative of cardiac flow with respect to the change of the delivery frequency of the stimulation pulses over the successive cardiac cycle is greater than a threshold;

means for evaluating a second condition if the first condition is met, the second condition being that the change of the parameter representative of cardiac flow is greater than a programmable variation (y %), wherein the means for adjusting the maximum frequency adjusts the maximum frequency when the second condition is not met; and

means for operating the means for adjusting the maximum frequency if the second condition is met in an iterative operation to control successive programmable variations of the delivery frequency of the stimulation pulses in response to the change in the parameter representative of cardiac flow with each iteration.

2. The active implantable medical device of claim 1, wherein the means for adjusting the maximum frequency further comprises means for terminating said iterative operation if the second condition is not met.

3. The active implantable medical device of claim 2, wherein said threshold is a fixed threshold.

4. The active implantable medical device of claim 2, wherein the means for adjusting the maximum frequency adjusts to the value of the delivery frequency of the stimulation pulses that had been applied to a penultimate iteration in response to the termination of the iteration operation.

5. The active implantable medical device of claim 1, wherein the means for adjusting the maximum frequency further comprises means for terminating the iteration operation in response to an increase of the delivery frequency of the stimulation pulses above a predetermined limit value.

6. The active implantable medical device of claim 1, wherein the means for measuring an intracardiac bio-impedance further comprises means for measuring a peak diastolic impedance and means for measuring a peak systolic impedance, and wherein the means for evaluating a parameter representative of cardiac flow utilizes the peak diastolic impedance and the peak systolic impedance.

7. The active implantable medical device of claim 1, wherein the means for measuring an intracardiac bio-impedance further comprises means for measuring a peak diastolic impedance and means for measuring a peak systolic impedance and wherein the means for evaluating a parameter representative of cardiac flow further comprises means for calculating the integrals of the measured intracardiac bio-impedance successive peaks of at least one of the group consisting of the peak diastolic impedance and the peak systolic impedance.

8. The active implantable medical device of claim 1, wherein said means for adjusting the maximum frequency further comprises means, after having adjusted the value of the maximum frequency, for adjusting at least one of the group consisting of a value of the atrio-ventricular delay and a value of the inter-ventricular delay.

9. The active implantable medical device of claim 8, wherein the means for adjusting the maximum frequency further comprises means for controlling a programmable variation of at least one of the group consisting of the atrio-ventricular delay and the inter-ventricular delay, means for evaluating the correlative variation of the cardiac flow, and means for adjusting at least one of the group consisting of the value of the atrio-ventricular delay and inter-ventricular delay according to the evaluated variation of the cardiac flow.

10. The active implantable medical device of claim 8, wherein the means for adjusting the frequency maximum further comprises means operating in an iterative way, to control successive programmable variations of at least one of the group consisting of the atrio-ventricular delay and inter-ventricular delay, and to evaluate with each iteration the correlative variation of the cardiac flow.

11. An active implantable medical device, having computer readable instructions stored in memory for performing the steps of:

delivering stimulation pulses to at least one site of a cardiac cavity;

controlling a delivery frequency of the stimulation pulses;

limiting to a maximum frequency the delivery frequency of the stimulation pulses;

measuring an intracardiac bio-impedance;

adjusting the maximum frequency to a value that is a function of the measured intracardiac bio-impedance;

evaluating a parameter representative of cardiac flow based upon a signal delivered by the means for measuring the intracardiac bio-impedance;

changing the delivery frequency of the stimulation pulses in a successive cardiac cycles, causing a change of the delivery frequency of the stimulation pulses by a programmable variation (X %);

measuring a change in the parameter representative of cardiac flow over the successive cardiac cycle;

evaluating a first condition, the first condition being that the ratio of the change in the parameter representative of cardiac flow with respect to the change of the delivery frequency of the stimulation pulses over the successive cardiac cycle is greater than a threshold;

evaluating a second condition if the first condition is met, the second condition being that the change of the parameter representative of cardiac flow is greater than a programmable variation (y %), wherein the maximum frequency is adjusted when the second condition is not met; and

adjusting the maximum frequency if the second condition is met in an iterative operation to control successive programmable variations of the delivery frequency of the stimulation pulses in response to the change in the parameter representative of cardiac flow with each iteration.