Sensor calibration

• US 7,711,506 B2
• Filed: 05/16/2006
• Issued: 05/04/2010
• Est. Priority Date: 05/17/2005
• Status: Expired due to Fees

• Current Assignee: Toumaz Technology Ltd.
• Original Assignee: Bio-Nano Sensium Technologies Limited
• Inventors: Burdett, Alison, Padden, Paul
• Primary Examiner(s): Bui; Bryan
• Application Number:
  US11/919,998
• Publication Number:
  US 20090093985A1
• Time in Patent Office: 1,449 Days
• Field of Search: 702/85, 702/91, 702/104, 600/485
• US Class Current: 702/91
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 2560/0412 Low-profile patch shaped housings
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes

Abstract

A method of calibrating a sensor system comprising a disposable sensor and a computer device, both the sensor and the computer device having circuitry for facilitating the transmission of data between them via a wireless communication link. The method comprises storing a final value of a monitored parameter obtained using a first disposable sensor, or some other value derivable from said final value, in a memory of the computer device, and calibrating the system for a new disposable sensor using said final value or said other value.

Claims

1. A method of calibrating a sensor system comprising a plurality of disposable sensors and a computer device, both the sensors and the computer device having circuitry for facilitating the transmission of data between them via a wireless communication link, the method comprising:

(a) using a first disposable sensor to monitor a parameter including sending data from the first disposable sensor to said computer device;

(b) storing a final value of a monitored parameter obtained using said first disposable sensor, or some other value derivable from said final value, in a memory of the computer device, and disposing of said first disposable sensor;

(c) installing a new disposable sensor including calibrating the sensor system for said new disposable sensor using said final value or said other value and repeating steps a) and b) for the new disposable sensor; and

d) repeating step c) for each further new disposable sensor.

2. A method according to claim 1 and comprising using said final value or other value to compute a calibration factor for said new or a further new disposable sensor.

3. A method according to claim 2, where said factor is a constant used to evaluate the parameter being monitored from a measured value.

4. A method according to claim 1, wherein the final value or said other value is sent from the computer device to said new or a further new disposable sensor where evaluation of the monitored parameter, or a part of the evaluation, is carried out at the sensor.

5. A method according to claim 1, wherein the final value or said other value is stored at the computer device where evaluation of the monitored parameter, or a part of the evaluation, is carried out.

6. A method according to claim 1, wherein said disposable sensor is wearable.

7. A method according to claim 1, wherein said disposable sensor is a pH sensor.

8. A method according to claim 1, wherein said disposable sensor is an ISFET based biosensor, and the measured value is the gate-source voltage of the ISFET or the voltage or current through the drain/source.

9. A method according to claim 1, wherein the system is arranged in use to determine a blood glucose level.

10. A method according to claim 9, wherein said final value is a blood glucose level.

11. A method according to claim 9, wherein blood glucose level is a function of pH, the pH being derivable from the equation:

V_T=V_os+2.3·

α

·

Vth·

pH

where Vth=thermal voltage=kT/q, and V_os is a process and chemical-dependent offset voltage which differs from sensor to sensor, and α

is a temperature and device dependent constant,

the step of calibrating the system comprising determining V_os based upon measurements made with said new or a further new sensor and the final pH value obtained for the first or previous sensor.

12. A method according to claim 1, said step of calibrating the system for said new or a further new disposable sensor being carried out upon power-up of the disposable sensor.

17. A method according to claim 2, wherein the final value or said other value, or said calibration factor, is sent from the computer device to said new or a further new disposable sensor where evaluation of the monitored parameter, or a part of the evaluation, is carried out at the sensor.

18. A method according to claim 2, wherein the final value or said other value, or said calibration factor, is stored at the computer device where evaluation of the monitored parameter, or a part of the evaluation, is carried out.

13. A sensor system comprising:

a plurality of disposable sensors, at least a portion of each sensor being arranged in use to come into contact with a substance; and

a computer device,

both the sensor and the computer device having circuitry for facilitating the transmission of data between them via a wireless communication link, the computer device further comprising a memory for storing a final value of a parameter being monitored, or some other value derivable from said final value, for a first disposable sensor, and processing means for using said final or other value to calibrate a second disposable sensor, wherein the computer device is arranged to repeat this procedure for each subsequent disposable sensor using the final value or other value monitored for the previous disposable sensor.

14. A system according to claim 13, the system being arranged in use to determine the blood glucose level of a user.

15. A system according to claim 13, each disposable sensor comprising means for signalling to the computer device that calibration is required, said step of calibrating the system being carried out upon receipt by the computer device of the signalled information.

16. A system according to claim 13, each disposable sensor comprising means for receiving said final value of the parameter being monitored from the computer device over the wireless link.