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Cytotoxic compounds and conjugates with cleavable substrates

  • US 7,714,016 B2
  • Filed: 04/06/2006
  • Issued: 05/11/2010
  • Est. Priority Date: 04/08/2005
  • Status: Active Grant
First Claim
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1. A compound having the following structure:


  • X2private use character ParenopenstL1private use character ParenclosestmD 



    (2)wherein L1 is a self-immolative spacer;

    m is an integer of 1, 2, 3, 4, 5, or 6;

    X2 is a cleavable substrate, wherein the cleavable substrate comprises a cephalosporin derivative; and

    D is a drug having the following formula;

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