Apparatus and method for forming a gas composition gradient between FAIMS electrodes
First Claim
Patent Images
1. An apparatus for separating ions, comprising:
- a first electrode and a second electrode disposed one relative to the other in a spaced-apart facing arrangement for defining an analyzer region therebetween, the analyzer region including a first end and a second end and having a length extending between the first end and the second end;
a first gas inlet in fluid communication with the analyzer region, for providing a flow of a carrier gas of a first composition;
a second gas inlet in fluid communication with the analyzer region, for providing a flow of a carrier gas of a second composition; and
,a gas-flow directing element in fluid communication with the first gas inlet and in fluid communication with the second gas inlet, for receiving the flow of the carrier gas of the first composition and the flow of the carrier gas of the second composition, and for providing within a portion of the analyzer region a carrier gas flow having a composition that is non-uniform in space.
1 Assignment
0 Petitions
Accused Products
Abstract
A method of separating ions includes providing a FAIMS analyzer region for separating ions, the FAIMS analyzer region in fluid communication with an ionization source and with an ion detecting device. The method further includes affecting a gas composition within a first portion of the FAIMS analyzer region to be different from a gas composition within a second portion of the FAIMS analyzer region. The establishment of a gas composition gradient within the FAIMS analyzer region enhances ion focusing and ion transport efficiency.
-
Citations
27 Claims
-
1. An apparatus for separating ions, comprising:
-
a first electrode and a second electrode disposed one relative to the other in a spaced-apart facing arrangement for defining an analyzer region therebetween, the analyzer region including a first end and a second end and having a length extending between the first end and the second end; a first gas inlet in fluid communication with the analyzer region, for providing a flow of a carrier gas of a first composition; a second gas inlet in fluid communication with the analyzer region, for providing a flow of a carrier gas of a second composition; and
,a gas-flow directing element in fluid communication with the first gas inlet and in fluid communication with the second gas inlet, for receiving the flow of the carrier gas of the first composition and the flow of the carrier gas of the second composition, and for providing within a portion of the analyzer region a carrier gas flow having a composition that is non-uniform in space. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
-
-
10. A method of separating ions, comprising:
-
providing a high field asymmetric waveform ion mobility spectrometry (FANS) analyzer region for separating ions; providing a flow of a carrier gas within a portion of the FAIMS analyzer region, the flow of carrier gas having a composition that is non-uniform in space along a direction transverse to the flow of the carrier gas; introducing ions into the FAIMS analyzer region; providing electric field conditions within the FAIMS analyzer region for selectively transmitting a subset of the ions through the FAIMS analyzer region; and
,selectively transmitting the subset of ions along an average ion flow path through the FAIMS analyzer region. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
-
Specification