Apparatus and method for high resolution temperature measurement and for hyperthermia therapy

• US 7,717,618 B2
• Filed: 12/30/2005
• Issued: 05/18/2010
• Est. Priority Date: 12/30/2005
• Status: Active Grant

• Current Assignee: Optech Ventures, LLC
• Original Assignee: Optech Ventures, LLC
• Inventors: Mukamal, Harold, Saxena, Indu
• Primary Examiner(s): Verbitsky; Gail
• Assistant Examiner(s): Jagan; Mirellys
• Application Number:
  US11/325,907
• Publication Number:
  US 20070156212A1
• Time in Patent Office: 1,600 Days
• Field of Search: 374/137, 374/121, 374/131, 374/161
• US Class Current: 374/137
• CPC Class Codes: A61B 18/18 by applying electromagnetic radiation, e.g. microwaves radiation therapy A61N5/00
• CPC Class Codes: A61B 2017/00057 Light
• CPC Class Codes: A61B 2017/00084 Temperature
• CPC Class Codes: A61B 2017/00274 Prostate operation, e.g. prostatectomy, turp, bhp treatment
• CPC Class Codes: A61B 2018/00547 Prostate
• CPC Class Codes: A61N 1/403 for thermotherapy, e.g. hyperthermia
• CPC Class Codes: A61N 5/025 Warming the body, e.g. hyperthermia treatment

Abstract

An apparatus and method for increasing the resolution of a linear array of fiber Bragg gratings by applying a plastic coating having a high CTE over the optical fiber. Apparatus and method for determining the temperature of each of a succession of points along a tissue portion during hyperthermia treatment includes an optical fiber with a succession of closely spaced fiber Bragg gratings. Each grating is responsive to a different wavelength and is sensitive to ambient temperature to change that wavelength as a function of temperature. A tunable laser operative continuously over a range of wavelengths including those to which the gratings respond is used to interrogate the gratings. Sensitivity-enhancing coatings are used on the fibers and the lasers are tuned over very short time cycles.

Claims

1. A hyperthermia therapy system comprising;

an electromagnetic radiation source adapted to cause increase of the temperature of a selected tissue area upon exposure to the electromagnetic radiation for hyperthermia therapy;

a temperature profiling portion of the system for measuring temperature changes caused by the electromagnetic radiation comprising;

an optical fiber temperature sensor comprising a series of FBGs spaced apart along an optical fiber sensor element, each FBG having a different reflection spectrum and a different specified characteristic peak wavelength adapted to be placed adjacently proximate tissue whose temperature is to be determined and monitored during hyperthermia treatment;

an interrogation portion coupled to the optical fiber temperature sensor comprising a scanning light source having a scanning rate defining scan cycles to send interrogating light to the optical fiber sensor, the scanning light source having a scanning wavelength range sufficiently broad to cause reflection by all of the FBGs such that each scanning cycle updates the reflection spectra of the FBGs;

a detection and processing portion for detecting the reflected light of the FBGs and determining therefrom the temperature and the temperature change locally to each FBG comprising;

a wavelength selective detector element coupled to receive reflected light from the FBGs and operative at a sampling rate to produce a time division electrical signal representative of the spectra reflected from each FBG;

a specially programmed processor in communication with the wavelength selective detector element to control its sampling rate and to convert the time divisions of the time division electrical digital signal to wavelength divisions and to identify wavelength peaks for each FBG in each of said scanning cycles by applying a curve smoothing and curve fitting and peak detection

procedure comprising;

sampling the signal at a sampling rate defined by;

$\frac{\mathrm{light}<br><br><br><br>\mathrm{source}<br><br><br><br>\mathrm{scanning}<br><br><br><br>\mathrm{rate}}{\mathrm{desired}<br><br><br><br>\mathrm{temperature}<br><br><br><br>\mathrm{resolution}\times <br><br>\mathrm{Kt}};<br><br>$

applying the sampling rate to the wavelength selective detector;

defining a bin for each FBG in which each bin has a lower wavelength limit and an upper wavelength limit which is not more than 1/2 the difference between the specified characteristic peak wavelength of the FBG and the specified characteristic peak wavelength of the next lower and the next higher FBG, respectively;

in each bin selecting a number of data points over which to smooth thereby creating a smoothing window having N data points;

replacing each of the data points in each smoothing window by the mean value of the set of data points consisting of N/2 data points preceding the data point and N/2 data points succeeding the data point defining a second set of data points;

curve fitting the second set of data points to a polynomial curve of order of at least two;

determining the peak of the polynomial curve to define a wavelength peak of each FBG;

taking the difference of the wavelength peak of each FBG at selected time intervals from a predetermined wavelength peak at a base condition and converting that wavelength difference to a temperature difference by multiplying by Kt; and

an output device adapted to provide a temperature profile at each of the selected time intervals comprising the temperature at each FBG and /or the temperature change at each FBG.