Method and apparatus for combining continuous wave and time domain optical imaging
First Claim
1. A method for optical imaging of a volume of interest (VOI) in a turbid medium, the method comprising:
- i) optically scanning the VOI at a plurality of source and detector geometries using continuous wave (CW) to generate CW data;
ii) optically scanning the VOI at a plurality of source and detector geometries using time-domain (TD) to generate data representing at least a portion of a measured temporal point spread function (TPSF), said TPSF data being measured from a plurality of light pulses from which a statistical average of light received as a function of time is obtained, said TPSF data yielding information about absorption and scatter within said VOI;
iii) combining information extracted from the CW data with the TPSF data to improve an accuracy of imaging using the measured TPSF data whereby an improved image accuracy of the VOI of the turbid medium is generated with fewer said light pulses and a shorter acquisition time by using both time-domain and continuous wave modalities; and
iv) generating an improved image of the VOI of the turbid medium.
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Abstract
There is provided methods and systems for optical imaging in a turbid medium that combine continuous wave (CW) and time domain (TD) approaches to substantially increase robustness of optical imaging as well as to reduce acquisition times associated with the TD approach. In one aspect, a method is provided that uses CW measurements to scale the values of a temporal point spread function (TPSF) to avoid physical unit mismatch problems. In another aspect, both CW and TD measurements are synergistically combined to estimate optical properties of the medium used in image reconstruction. Optical systems capable of realizing these methods are also provided.
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Citations
30 Claims
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1. A method for optical imaging of a volume of interest (VOI) in a turbid medium, the method comprising:
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i) optically scanning the VOI at a plurality of source and detector geometries using continuous wave (CW) to generate CW data; ii) optically scanning the VOI at a plurality of source and detector geometries using time-domain (TD) to generate data representing at least a portion of a measured temporal point spread function (TPSF), said TPSF data being measured from a plurality of light pulses from which a statistical average of light received as a function of time is obtained, said TPSF data yielding information about absorption and scatter within said VOI; iii) combining information extracted from the CW data with the TPSF data to improve an accuracy of imaging using the measured TPSF data whereby an improved image accuracy of the VOI of the turbid medium is generated with fewer said light pulses and a shorter acquisition time by using both time-domain and continuous wave modalities; and iv) generating an improved image of the VOI of the turbid medium. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for optical imaging of a volume of interest (VOI) in a turbid medium, the method comprising:
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i) obtaining continuous wave (CW) data to generate an image of a part of the medium comprising the VOI; ii) generating the image of the part of the medium comprising the VOI; iii) localizing the VOI within the part of the medium using information from the generated image; iv) obtaining time-domain (TD) data from the localized VOI to generate an image of the localized VOI in the turbid medium; and v) generating the image of the localized VOI in the turbid medium.
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14. A method for optical imaging of a volume of interest (VOI) in a turbid medium, the method comprising:
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i) obtaining continuous wave (CW) data to generate an image of a part of the medium comprising the VOI; ii) generating the image of the part of the medium comprising the VOI; iii) localizing the VOI within the part of the medium using information from the generated image; iv) optimizing TD image acquisition parameters using the CW data; v) obtaining TD data from the VOI using the optimized TD image acquisition parameters to generate an image of the localized VOI in the turbid medium; and vi) generating the image of the localized VOI in the turbid medium. - View Dependent Claims (15)
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16. An optical imaging system for imaging a turbid media object, the apparatus comprising:
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at least one optical source for providing continuous and pulsed optical energy; at least one optical detector for detecting optical energy and generating time-dependent and continuous data; a first optical coupling for coupling said optical source to a desired position on said object; a second optical coupling for coupling said optical detector to a desired position on said object; an acquisition controller connected to said optical source and said optical detector for collecting said time-dependent and continuous data for a plurality of geometries within a volume of interest in said object; a continuous-wave photon migration model calculator; a time-domain photon migration model calculator; and an estimator using said continuous data and calculated values corresponding to said continuous data to improve a determination of optical properties of said object using said time-dependent data and calculated values corresponding to said time-dependent data. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification