Non-destructive systems, devices, and methods for evaluating iontophoresis drug delivery devices
First Claim
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1. A method for evaluating iontophoretic delivery devices, the method comprising:
- applying at least a first test signal to an iontophoresis delivery device being evaluated;
measuring at least one resistive or capacitive response of the iontophoresis delivery device being evaluated to at least the first test signal;
comparing at least a first value indicative of the measured at least one resistive or capacitive response of the iontophoresis delivery device to one or more reference data sets indicative of at least one resistive or capacitive response of at least one reference iontophoresis delivery device; and
determining whether the iontophoresis delivery device being evaluated meets an acceptance criteria based at least in part on the comparison, wherein applying at least a first test signal to an iontophoresis delivery device being evaluated includes applying an alternating current to the iontophoretic delivery device.
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Abstract
Systems, devices, and methods for evaluating iontophoresis devices. An impedance spectrometer is operable to determine an impedance of an iontophoresis device and a controller configured to perform a comparison of the measured impedance of the iontophoresis device to stored reference data, and to generate a response based in part on the comparison.
20 Citations
18 Claims
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1. A method for evaluating iontophoretic delivery devices, the method comprising:
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applying at least a first test signal to an iontophoresis delivery device being evaluated; measuring at least one resistive or capacitive response of the iontophoresis delivery device being evaluated to at least the first test signal; comparing at least a first value indicative of the measured at least one resistive or capacitive response of the iontophoresis delivery device to one or more reference data sets indicative of at least one resistive or capacitive response of at least one reference iontophoresis delivery device; and determining whether the iontophoresis delivery device being evaluated meets an acceptance criteria based at least in part on the comparison, wherein applying at least a first test signal to an iontophoresis delivery device being evaluated includes applying an alternating current to the iontophoretic delivery device. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for evaluating iontophoretic delivery devices, the method comprising:
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applying at least a first test signal to an iontophoresis delivery device being evaluated; measuring at least one resistive or capacitive response of the iontophoresis delivery device being evaluated to at least the first test signal; comparing at least a first value indicative of the measured at least one resistive or capacitive response of the iontophoresis delivery device to one or more reference data sets indicative of at least one resistive or capacitive response of at least one reference iontophoresis delivery device; and determining whether the iontophoresis delivery device being evaluated meets an acceptance criteria based at least in part on the comparison, wherein applying at least a first test signal to an iontophoresis delivery device being evaluated includes applying a first alternating current of a first frequency to the iontophoretic delivery device being evaluated at a first time and applying a second alternating current of a second frequency to the iontophoretic delivery device being evaluated at a second time, the second frequency different than the first frequency. - View Dependent Claims (9)
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10. A system for evaluating iontophoresis devices, comprising:
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an impedance spectrometer operable to measure an impedance of an iontophoresis device; a database comprising stored iontophoresis device reference data; a controller configured to perform a comparison of the measured impedance of the iontophoresis device to the stored reference data, and to generate a response based in part on the comparison, wherein the impedance spectrometer includes at least one frequency response analyzer (FRA), and is configured to determine the impedance of the iontophoresis device for at least two selected frequencies of an alternating current. - View Dependent Claims (11, 12, 13, 14, 15)
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16. A system for evaluating iontophoresis devices, comprising:
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an impedance spectrometer operable to measure an impedance of an iontophoresis device; a database comprising stored iontophoresis device reference data; a controller configured to perform a comparison of the measured impedance of the iontophoresis device to the stored reference data, and to generate a response based in part on the comparison, wherein the stored reference data comprises impedance data, characteristic phase delay data, characteristic amplitude data, characteristic resistance data, characteristic electrolyte resistance data, characteristic interface capacitance data, and characteristic ionic movement data. - View Dependent Claims (17, 18)
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Specification