Method and apparatus for detection of multiple analytes
First Claim
1. An apparatus for analyzing the composition of bodily fluid, the apparatus comprising:
- a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient;
at least one pump in operative engagement with the fluid handling network, the at least one pump having a sample draw mode in which the pump is operable to draw a sample of the bodily fluid from the patient through the patient end;
a controller configured to operate the at least one pump in the sample draw mode at intervals;
a fluid analyzer positioned to analyze at least a portion of the sample;
a processor in communication with or incorporated into the fluid analyzer;
and stored program instructions executable by the processor to determine the concentrations of two or more analytes in the sample, wherein the program instructions are configured to cause the fluid analyzer to;
subject the at least a portion of the sample to one or more tests;
analyze results from the one or more tests to estimate the concentration of a first analyte;
determine whether the results from the one or more tests are sensitive to a second analyte in the sample; and
analyze the at least a portion of the sample to estimate the concentration of the second analyte, wherein analyzing the at least a portion of the sample comprises analyzing the same results from the one or more tests when it is determined that the results from spectral features of the second analyte overlap spectral features of the first analyte.
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Accused Products
Abstract
An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and at least one pump intermittently operable to draw a sample of bodily fluid from the patient. The apparatus further comprises a fluid analyzer positioned to analyze at least a portion of the sample and measure the presence of two or more analytes. Also disclosed is a method for analyzing the composition of a bodily fluid in a patient. The method comprises drawing a sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient. The method further comprises analyzing the at least a portion of the sample in a fluid analyzer to estimate the concentration of two or more analytes in the sample.
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Citations
21 Claims
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1. An apparatus for analyzing the composition of bodily fluid, the apparatus comprising:
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a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient; at least one pump in operative engagement with the fluid handling network, the at least one pump having a sample draw mode in which the pump is operable to draw a sample of the bodily fluid from the patient through the patient end; a controller configured to operate the at least one pump in the sample draw mode at intervals; a fluid analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the fluid analyzer; and stored program instructions executable by the processor to determine the concentrations of two or more analytes in the sample, wherein the program instructions are configured to cause the fluid analyzer to; subject the at least a portion of the sample to one or more tests; analyze results from the one or more tests to estimate the concentration of a first analyte; determine whether the results from the one or more tests are sensitive to a second analyte in the sample; and analyze the at least a portion of the sample to estimate the concentration of the second analyte, wherein analyzing the at least a portion of the sample comprises analyzing the same results from the one or more tests when it is determined that the results from spectral features of the second analyte overlap spectral features of the first analyte. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for automatically analyzing the composition of a bodily fluid in a patient, the method comprising:
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a) automatically drawing a sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient; b) directing at least a portion of the sample to a fluid analyzer connected to the fluid handling network; c) obtaining a spectral characterization of at least a portion of the sample in the fluid analyzer; d) analyzing the spectral characterization to estimate the concentration of a first analyte in the sample, the first analyte being apart from any interferents to the measurement of the first analyte; e) determining whether a second analyte in the sample is associated with spectral features that overlap spectral features associated with the first analyte, the second analyte being apart from any interferents to the measurement of the second analyte; f) analyzing the at least a portion of the sample to estimate the concentration of the second analyte, wherein analyzing the at least a portion of the sample comprises analyzing the spectral characterization when spectral features of the second analyte overlap spectral features of the first analyte; g) automatically drawing another sample of the bodily fluid of the patient through the fluid handling network after an interval has elapsed; and h) repeating steps b)-f) using the newly-drawn sample. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21)
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Specification