Use of a biological material containing three-dimensional scaffolds of hyaluronic acid derivatives for the preparation of implants in arthroscopy and kit for instruments for implanting said biological material by arthroscopy
First Claim
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1. A method for the treatment of a cartilage lesion by implantation of a graft at the cartilage lesion site by arthroscopic techniques, said method comprising the steps of:
- preparing an autologous and/or allogenic graft comprising a biological material suitable for implantation by arthroscopic techniques, bygrowing autologous and/or allogenic cells chosen from the group consisting of chondrocytes, osteocytes, mesenchymal cells, and stem cells onto three-dimensional scaffolds, for a period of time of seven to fourteen days, wherein said scaffolds comprise at least one hyaluronic acid derivative that is an ester of hyaluronic acid, wherein part or all of the carboxy functions of said hyaluronic acid are esterified with alcohols of the arylaliphatic series;
circumscribing the cartilage lesion by creating a circular imprint by means of a mapper-sampler;
cutting out and removing a piece of damaged cartilage tissue having the same size and shape as the imprint;
preparing the so obtained biological material for arthroscopic implantation by reducing said biological material by means of the mapper-sampler to the size and shape of said imprint;
introducing the so reduced biological material into a cannula and applying the same to the cartilage lesion site.
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Abstract
The invention relates to use of a biological material containing cells supported on three-dimensional scaffolds containing at least one hyaluronic acid derivative for the preparation of grafts suitable for application by arthroscopy, and a kit of surgical instruments for implanting said biological material by arthroscopy.
22 Citations
11 Claims
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1. A method for the treatment of a cartilage lesion by implantation of a graft at the cartilage lesion site by arthroscopic techniques, said method comprising the steps of:
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preparing an autologous and/or allogenic graft comprising a biological material suitable for implantation by arthroscopic techniques, by growing autologous and/or allogenic cells chosen from the group consisting of chondrocytes, osteocytes, mesenchymal cells, and stem cells onto three-dimensional scaffolds, for a period of time of seven to fourteen days, wherein said scaffolds comprise at least one hyaluronic acid derivative that is an ester of hyaluronic acid, wherein part or all of the carboxy functions of said hyaluronic acid are esterified with alcohols of the arylaliphatic series; circumscribing the cartilage lesion by creating a circular imprint by means of a mapper-sampler; cutting out and removing a piece of damaged cartilage tissue having the same size and shape as the imprint; preparing the so obtained biological material for arthroscopic implantation by reducing said biological material by means of the mapper-sampler to the size and shape of said imprint; introducing the so reduced biological material into a cannula and applying the same to the cartilage lesion site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification