Agents that modulate the interaction of B7-1 polypeptide with PD-L1 and methods of use thereof
First Claim
1. A method for inhibiting the interaction between a B7-1 polypeptide and a PD-L1 polypeptide, comprising:
- a) contacting an immune cell bearing a PD-L1 polypeptide;
orb) contacting an immune cell bearing a B7-1 polypeptide;
with an agent that inhibits the interaction between the PD-L1 polypeptide and the B7-1 polypeptide.
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Accused Products
Abstract
Disclosed are methods for modulating an immune response including a method for inhibiting the interaction between a B7 polypeptide and a PD-1 ligand, the method comprising contacting an immune cell bearing a PD-1 ligand, or an immune cell bearing a B7 polypeptide, with an agent that inhibits the interaction between the PD-1 ligand and the B7 polypeptide. Such agents may be an anti-PD-1 ligand antibody or a small molecule. Also disclosed is a method for modulating an immune response comprising contacting an immune cell bearing the PD-1 ligand, or an immune cell bearing the PD-1 polypeptide, with an agent that inhibits interactions between the PD-1 ligand and the PD-1 polypeptide, without inhibiting interactions between the PD-1 ligand and a B7 polypeptide, to thereby modulate an immune response. The agent may be an anti-PD-1 ligand antibody or a small molecule.
61 Citations
7 Claims
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1. A method for inhibiting the interaction between a B7-1 polypeptide and a PD-L1 polypeptide, comprising:
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a) contacting an immune cell bearing a PD-L1 polypeptide;
orb) contacting an immune cell bearing a B7-1 polypeptide; with an agent that inhibits the interaction between the PD-L1 polypeptide and the B7-1 polypeptide. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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Specification