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Agents that modulate the interaction of B7-1 polypeptide with PD-L1 and methods of use thereof

  • US 7,722,868 B2
  • Filed: 08/09/2006
  • Issued: 05/25/2010
  • Est. Priority Date: 11/13/2001
  • Status: Active Grant
First Claim
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1. A method for inhibiting the interaction between a B7-1 polypeptide and a PD-L1 polypeptide, comprising:

  • a) contacting an immune cell bearing a PD-L1 polypeptide;

    orb) contacting an immune cell bearing a B7-1 polypeptide;

    with an agent that inhibits the interaction between the PD-L1 polypeptide and the B7-1 polypeptide.

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