Methods of predicting therapeutic response in atopic dermatitis to IL-31 antagonists
First Claim
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1. A method of predicting the therapeutic response to an IL-31 antibody in an individual with atopic dermatitis comprising the steps of:
- a. obtaining a blood sample from the individual;
b. obtaining a blood sample from a control;
c. isolating circulating cutaneous lymphocyte positive T cells from the samples;
d. activating the isolated cells with 0.5 ug/ml of anti-CD3 antibody;
e. detecting IL-31 production from the isolated cutaneous lymphocyte positive T cells; and
f. correlating a greater amount of IL-31 production in the individual versus the control with a therapeutic response to the IL-31 antibody.
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Abstract
The present invention relates to predicting therapeutic response of treating patients suffering from itching and puritis mediated by cutaneous lymphocyte antigen positive T cells in atopic dermatitis. The invention also includes methods of predicting a therapeutically responsive patient population.
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4 Claims
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1. A method of predicting the therapeutic response to an IL-31 antibody in an individual with atopic dermatitis comprising the steps of:
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a. obtaining a blood sample from the individual; b. obtaining a blood sample from a control; c. isolating circulating cutaneous lymphocyte positive T cells from the samples; d. activating the isolated cells with 0.5 ug/ml of anti-CD3 antibody; e. detecting IL-31 production from the isolated cutaneous lymphocyte positive T cells; and f. correlating a greater amount of IL-31 production in the individual versus the control with a therapeutic response to the IL-31 antibody. - View Dependent Claims (2, 3, 4)
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