Diagnosing and treating hematopoietic cancers
First Claim
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1. A method of determining whether a mammal has acute lymphoblastic leukemias (ALL) or acute myeloid leukemias (AML), the method comprising:
- providing a biological sample comprising a test cell from the mammal, wherein the test cell is a lymphoid cell or a myeloid cell; and
determining the level of Wnt5a mRNA within the test cell, wherein a significantly reduced level of Wnt5a mRNA in the test cell, relative to that in a non-cancerous control lymphoid or myeloid cell of the same type as the test cell, indicates that the mammal has ALL or AML.
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Abstract
Described herein are methods and compositions comprising Wnt5a for the diagnosis and treatment of hematopoietic cancers, and methods of identifying therapeutic compounds for the treatment of hematopoietic cancers.
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10 Claims
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1. A method of determining whether a mammal has acute lymphoblastic leukemias (ALL) or acute myeloid leukemias (AML), the method comprising:
- providing a biological sample comprising a test cell from the mammal, wherein the test cell is a lymphoid cell or a myeloid cell; and
determining the level of Wnt5a mRNA within the test cell, wherein a significantly reduced level of Wnt5a mRNA in the test cell, relative to that in a non-cancerous control lymphoid or myeloid cell of the same type as the test cell, indicates that the mammal has ALL or AML. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
- providing a biological sample comprising a test cell from the mammal, wherein the test cell is a lymphoid cell or a myeloid cell; and
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