Stable aqueous antimicrobial enzyme compositions comprising a tertiary amine antimicrobial

• US 7,723,281 B1
• Filed: 01/20/2009
• Issued: 05/25/2010
• Est. Priority Date: 01/20/2009
• Status: Active Grant

• Current Assignee: Ecolab USA Incorporated (Ecolab, Inc.)
• Original Assignee: Ecolab, Inc.
• Inventors: Strothoff, Werner, Siegmann, Alice, Herdt, Brandon L.
• Primary Examiner(s): Boyer; Charles I
• Application Number:
  US12/356,435
• Time in Patent Office: 490 Days
• Field of Search: 510/161, 510/214, 510/238, 510/253, 510/300, 510/320, 510/392, 510/382, 510/432, 510/480, 510/499
• US Class Current: 510/214
• CPC Class Codes: C11D 3/2068 Ethers
• CPC Class Codes: C11D 3/2075 Carboxylic acids-salts thereof
• CPC Class Codes: C11D 3/30 Amines; Substituted amines ; Quaternized amines
• CPC Class Codes: C11D 3/33 Amino carboxylic acids
• CPC Class Codes: C11D 3/38627 containing lipase
• CPC Class Codes: C11D 3/43 Solvents
• CPC Class Codes: C11D 3/48 Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Abstract

The invention relates to an enzyme stabilization system, compositions with the enzyme stabilization system, and methods of using the enzyme composition. Preferred ratios of acid to amine are effective at stabilizing enzyme. Optional nonionic surfactants and solvents also positively contribute to enzyme stability. The compositions are useful in cleaning applications.

Claims

1. A concentrated antimicrobial enzymatic floor cleaning composition comprising:

a) a tertiary amine antimicrobial;

b) a lipase;

c) an organic acid;

d) a surfactant;

e) a glycol ether solvent;

f) an aminocarboxylate selected from the group consisting of methylglycinediacetic acid, glutamic-N,N-diacetic acid, and salts thereof; and

g) about 50-80% water,

wherein the total concentration of the surfactant, solvent and aminocarboxylate is from about 3.0 to about 50 wt. %, the ratio of the tertiary amine to the total concentration of the surfactant, solvent and aminocarboxylate is about (0.02-0.4);

1, the composition has a pH range from about 4.9 to about 9.5, the composition has 15% of its original enzyme activity after 21 days at a temperature of 40°

C., and the composition is free of boric acid or a boric acid salt.

2. The composition of claim 1, wherein ratio of organic acid:

amine is between about 1;

0.46 and about 1;

2.85.

3. The composition of claim 1, wherein the organic acid is acetic acid.

8. The composition according to claim 1 or 4, wherein the composition is configured for use in a hard surface detergent composition.

9. The composition according to claim 1 or 4, wherein the composition is configured for use in a floor cleaning composition.

10. The composition according to claim 1 or 4, wherein the composition is configured for use in a clean-in-place composition.

11. The composition according to claim 1 or 4, wherein the composition is configured for use in an endoscope reprocessing composition.

4. A concentrated antimicrobial enzymatic floor cleaning composition comprising:

a) a tertiary amine antimicrobial;

b) an enzyme;

c) acetic acid;

d) a surfactant;

e) a glycol ether solvent;

f) an aminocarboxylate selected from the group consisting of methylglycinediacetic acid, glutamic-N,N-diacetic acid, and salts thereof; and

g) about 50-80% water,

wherein the total concentration of the surfactant, solvent and aminocarboxylate is from about 3.0 to about 50 wt. %, the ratio of the tertiary amine to the total concentration of the surfactant, solvent and aminocarboxylate is about (0.02-0.4);

1, the composition has a pH range from about 4.9 to about 9.5, the composition has 15% of its original enzyme activity after 21 days at a temperature of 40°

C., and the composition is free of boric acid or a boric acid salt.

5. The composition of claim 4, wherein ratio of acid:

amine is between about 1;

0.46 and about 1;

2.85.

6. The composition of claim 4, wherein the aminocarboxylate is methylglycinediacetic acid.

7. The composition of claim 4, wherein the surfactant is a nonionic surfactant.