Pancreatic polypeptide family motifs, polypeptides and methods comprising the same

• US 7,723,471 B2
• Filed: 12/12/2005
• Issued: 05/25/2010
• Est. Priority Date: 02/11/2004
• Status: Expired due to Fees

• Current Assignee: Astrazeneca Pharmaceuticals LP (Astrazeneca PLC)
• Original Assignee: Amylin Pharmaceuticals Incorporated (Bristol-Myers Squibb Company)
• Inventors: D'Souza, Lawrence J., Parkes, David G., Levy, Odile Esther, Pittner, Richard A., Ghosh, Soumitra S., Jodka, Carolyn M., Prickett, Kathryn S., Roth, Jonathan David, Ahn, John S., Adams, Sean H.
• Primary Examiner(s): Tsang; Cecilia
• Assistant Examiner(s): HEARD, THOMAS SWEENEY
• Application Number:
  US11/301,744
• Publication Number:
  US 20060135747A1
• Time in Patent Office: 1,625 Days
• Field of Search: None
• US Class Current: 530/324
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 38/1709 from mammals
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 1/16 for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07K 14/475 Growth factors; Growth regulators
• CPC Class Codes: C07K 14/575 Hormones derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin C07K14/665, e.g. corticotropin C07K14/695

Abstract

The present invention provides novel Pancreatic Polypeptide Family (“PPF”) polypeptides and methods for their use.

Claims

1. A PPF polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:

266, 267, 274, 282, 320, 436, 437, 438, 439, 440, 441, 442, 443, 444, 445, 446, 447, 448, 449, 450, 451, 453, 454, 455, 456, 457, 458, 459, 460, 461, 462, 463, 464, 465, 466, 467, 468, 469, 470, 471, 472, 473, 474, 475, 476, 477, 478, 479 and 480.

2. The PPF polypeptide of claim 1, wherein said polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:

282, 320, 437, 441, 444, 445 to 447, 452, 454 to 459, 461 to 464, 466, 468 to 470 and 472 to 480.

3. The PPF polypeptide of claim 1, wherein said polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:

266, 437, 438, 439, 442, 462, 469, 470, 471 and 472.

4. The PPF polypeptide of claim 1, wherein said polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:

437, 462, 469, 470 and 472.

5. A PPF polypeptide comprising SEQ ID NO:

266.

6. A PPF polypeptide comprising SEQ ID NO:

267.

7. A PPF polypeptide comprising SEQ ID NO:

274.

8. A PPF polypeptide comprising SEQ ID NO:

282.

9. A PPF polypeptide comprising SEQ ID NO:

320.

10. A PPF polypeptide comprising SEQ ID NO:

436.

11. A PPF polypeptide comprising SEQ ID NO:

437.

12. A PPF polypeptide comprising SEQ ID NO:

438.

13. A PPF polypeptide comprising SEQ ID NO:

439.

14. A PPF polypeptide comprising SEQ ID NO:

440.

15. A PPF polypeptide comprising SEQ ID NO:

441.

16. A PPF polypeptide comprising SEQ ID NO:

442.

17. A PPF polypeptide comprising SEQ ID NO:

474.

18. A PPF polypeptide comprising SEQ ID NO:

443.

19. A PPF polypeptide comprising SEQ ID NO:

444.

20. A PPF polypeptide comprising SEQ ID NO:

445.

21. A PPF polypeptide comprising SEQ ID NO:

446.

22. A PPF polypeptide comprising SEQ ID NO:

447.

23. A PPF polypeptide comprising SEQ ID NO:

448.

24. A PPF polypeptide comprising SEQ ID NO:

449.

25. A PPF polypeptide comprising SEQ ID NO:

450.

26. A PPF polypeptide comprising SEQ ID NO:

451.

27. A PPF polypeptide comprising SEQ ID NO:

453.

28. A PPF polypeptide comprising SEQ ID NO:

454.

29. A PPF polypeptide comprising SEQ ID NO:

455.

30. A PPF polypeptide comprising SEQ ID NO:

456.

31. A PPF polypeptide comprising SEQ ID NO:

457.

32. A PPF polypeptide comprising SEQ ID NO:

458.

33. A PPF polypeptide comprising SEQ ID NO:

459.

34. A PPF polypeptide comprising SEQ ID NO:

460.

35. A PPF polypeptide comprising SEQ ID NO:

461.

36. A PPF polypeptide comprising SEQ ID NO:

462.

37. A PPF polypeptide comprising SEQ ID NO:

463.

38. A PPF polypeptide comprising SEQ ID NO:

464.

39. A PPF polypeptide comprising SEQ ID NO:

465.

40. A PPF polypeptide comprising SEQ ID NO:

466.

41. A PPF polypeptide comprising SEQ ID NO:

467.

42. A PPF polypeptide comprising SEQ ID NO:

468.

43. A PPF polypeptide comprising SEQ ID NO:

469.

44. A PPF polypeptide comprising SEQ ID NO:

470.

45. A PPF polypeptide comprising SEQ ID NO:

471.

46. A PPF polypeptide comprising SEQ ID NO:

472.

47. A PPF polypeptide comprising SEQ ID NO:

473.

48. A PPF polypeptide comprising SEQ ID NO:

475.

49. A PPF polypeptide comprising SEQ ID NO:

476.

50. A PPF polypeptide comprising SEQ ID NO:

477.

51. A PPF polypeptide comprising SEQ ID NO:

478.

52. A PPF polypeptide comprising SEQ ID NO:

479.

53. A PPF polypeptide comprising SEQ ID NO:

480.