Method of photodynamically diagnosing or treating a contoured surface

• US 7,723,910 B2
• Filed: 03/09/2007
• Issued: 05/25/2010
• Est. Priority Date: 05/01/1998
• Status: Expired due to Fees

• Current Assignee: Dusa Pharmaceuticals (Sun Pharmaceutical Industries Limited)
• Original Assignee: Dusa Pharmaceuticals (Sun Pharmaceutical Industries Limited)
• Inventors: Lundahl, Scott, Carroll, Ronald, Kozodoy, Rebecca, Leppelmeier, Elton
• Primary Examiner(s): Williams; Joseph L
• Application Number:
  US11/716,014
• Publication Number:
  US 20070249716A1
• Time in Patent Office: 1,173 Days
• Field of Search: 607 88- 94, 313485-487, 600/476
• US Class Current: 313/485
• CPC Class Codes: A61B 2017/00057 Light
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61N 2005/0642 Irradiating part of the body at a certain distance
• CPC Class Codes: A61N 2005/0655 Tubes
• CPC Class Codes: A61N 5/0616 Skin treatment other than tanning
• CPC Class Codes: A61N 5/0617 Hair treatment
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent

Abstract

A method of photodynamically diagnosing or treating a contoured surface includes topically applying 5-aminolevulinic acid to the contoured surface and irradiating the contoured surface with substantially uniform intensity visible light from a plurality of light sources generally conforming to the contoured surface. The plurality of light sources may comprise fluorescent tubes.

Claims

1. A method of photodynamically diagnosing or treating a contoured surface, comprising:

topically applying 5-aminolevulinic acid to the contoured surface; and

irradiating the contoured surface with substantially uniform intensity visible light from a plurality of light sources generally conforming to the contoured surface,

wherein the plurality of light sources comprises fluorescent tubes.

2. The method according to claim 1, wherein the 5-aminolevulinic acid is in a carrier.

3. The method according to claim 1, further comprising:

applying 5-aminolevulinic acid in successive applications.

4. The method according to claim 1, comprising the step of topically applying 5-aminolevulinic acid to the contoured surface and irradiating the contoured surface to treat actinic keratosis.

5. The method according to claim 4, comprising the step of admixing the 5-aminolevulinic acid with a vehicle just prior to its use.

6. The method according to claim 1, comprising the step of topically applying 5-aminolevulinic acid to the contoured surface and irradiating the contoured surface to treat acne.

7. The method according to claim 6, comprising the step of admixing the 5-aminolevulinic acid with a vehicle just prior to its use.

8. The method according to claim 1, comprising the step of topically applying 5-aminolevulinic acid to the contoured surface and irradiating the contoured surface to treat photo damaged skin.

9. The method according to claim 8, comprising the step of admixing the 5-aminolevulinic acid with a vehicle just prior to its use.

10. The method according to claim 1, comprising the step of topically applying 5-aminolevulinic acid to the contoured surface and irradiating the contoured surface to treat cancer.

11. The method according to claim 10, comprising the step of admixing the 5-aminolevulinic acid with a vehicle just prior to its use.

12. The method according to claim 1, comprising the step of topically applying 5-aminolevulinic acid to the contoured surface and irradiating the contoured surface to treat warts.

13. The method according to claim 12, comprising the step of admixing the 5-aminolevulinic acid with a vehicle just prior to its use.

14. The method according to claim 1, comprising the step of topically applying 5-aminolevulinic acid to the contoured surface and irradiating the contoured surface to treat psoriasis.

15. The method according to claim 14, comprising the step of admixing the 5-aminolevulinic acid with a vehicle just prior to its use.

16. The method according to claim 1, comprising the step of topically applying 5-aminolevulinic acid to the contoured surface and irradiating the contoured surface to remove hair.

17. The method according to claim 16, comprising the step of admixing the 5-aminolevulinic acid with a vehicle just prior to its use.

18. The method according to claim 1, comprising the step of topically applying 5-aminolevulinic acid to the contoured surface and irradiating the contoured surface to diagnose cancer.

19. The method according to claim 18, comprising the step of admixing the 5-aminolevulinic acid with a vehicle just prior to its use.

20. The method according to claim 1, comprising the step of topically applying 5-aminolevulinic acid to the contoured surface and irradiating the contoured surface to treat a pre-cancerous condition.

21. The method according to claim 20, comprising the step of admixing the 5-aminolevulinic acid with a vehicle just prior to its use.

22. The method according to claim 1, comprising the step of admixing the 5-aminolevulinic acid with a vehicle just prior to its use.

23. The method according to claim 1, wherein the contoured surface is irradiated with light substantially entirely within the blue region.

25. The method according to claim 1, comprising the step of admixing the 5-aminolevulinic acid with a vehicle just prior to its use.

24. A method of photodynamically diagnosing or treating a contoured surface, comprising:

topically applying 5-aminolevulinic acid to the contoured surface; and

irradiating the contoured surface with substantially uniform intensity visible light from a plurality of light sources generally conforming to the contoured surface,

wherein the contoured surface is irradiated with light substantially entirely within the blue region.

26. A method of photodynamically diagnosing or treating a contoured surface, comprising:

topically applying 5-aminolevulinic acid to the contoured surface; and

irradiating the contoured surface with substantially uniform intensity visible light from a plurality of light sources generally conforming to the contoured surface,

wherein said irradiating comprises approximately 1000 seconds of light having a nominal peak wavelength of 417±

5 nanometers and a nominal bandwidth of 30 nanometers.