Sensor with layered electrodes
First Claim
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1. A flexible analyte sensor comprising:
- a base layer;
a first electrode layer disposed on the base layer and including a first electrode;
a first insulative layer disposed on the first electrode layer and having opposed first and second longitudinal ends, wherein said first insulative layer leaves at least a portion of the first electrode exposed through a first aperture, said first aperture being disposed longitudinally between, and away from, said first and second longitudinal ends of the first insulative layer;
a second electrode layer disposed on the first insulative layer and including a second electrode; and
a second insulative layer disposed on the second electrode layer and having opposed first and second longitudinal ends, wherein said second insulative layer leaves at least a portion of the second electrode exposed through a second aperture, said second aperture being disposed longitudinally between, and away from, said first and second longitudinal ends of the second insulative layer,wherein the maximum height of the sensor is about 25 microns.
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Abstract
A thin film sensor, such as a glucose sensor, is provided for transcutaneous placement at a selected site within the body of a patient. The sensor includes several sensor layers that include conductive layers and includes a proximal segment defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment with sensor electrodes for transcutaneous placement. The sensor electrode layers are disposed generally above each other, for example with the reference electrode above the working electrode and the working electrode above the counter electrode. The electrode layers are separated by dielectric layer.
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Citations
46 Claims
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1. A flexible analyte sensor comprising:
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a base layer; a first electrode layer disposed on the base layer and including a first electrode; a first insulative layer disposed on the first electrode layer and having opposed first and second longitudinal ends, wherein said first insulative layer leaves at least a portion of the first electrode exposed through a first aperture, said first aperture being disposed longitudinally between, and away from, said first and second longitudinal ends of the first insulative layer; a second electrode layer disposed on the first insulative layer and including a second electrode; and a second insulative layer disposed on the second electrode layer and having opposed first and second longitudinal ends, wherein said second insulative layer leaves at least a portion of the second electrode exposed through a second aperture, said second aperture being disposed longitudinally between, and away from, said first and second longitudinal ends of the second insulative layer, wherein the maximum height of the sensor is about 25 microns. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. An analyte monitoring system comprising:
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a flexible analyte sensor comprising; a base layer; a first electrode layer disposed on the base layer and including a first electrode; a first insulative layer disposed on the first electrode layer and having opposed first and second longitudinal ends, wherein said first insulative layer leaves at least a portion of the first electrode exposed through a first aperture, said first aperture being disposed longitudinally between, and away from, said first and second longitudinal ends of the first insulative layer; a second electrode layer disposed on the first insulative layer and including a second electrode; a second insulative layer disposed on the second electrode layer and having opposed first and second longitudinal ends, wherein said second insulative layer leaves at least a portion of the second electrode exposed through a second aperture, said second aperture being disposed longitudinally between, and away from, said first and second longitudinal ends of the second insulative layer; and a third electrode layer disposed on the second insulative layer and including a third electrode, wherein the first electrode layer further includes a first conductive trace leading from the first electrode to a first conductive pad adapted to electrically couple to sensor electronics, the second electrode layer further includes a second conductive trace leading from the second electrode to a second conductive pad adapted to electrically couple to sensor electronics, the third electrode layer further includes a third conductive trace leading from the third electrode to a third conductive pad adapted to electrically couple to sensor electronics, and the maximum height of the sensor is about 25 microns; sensor electronics electrically connected to the first, second and third conductive pads; and an analyte monitor; wherein the sensor electronics and the analyte monitor are adapted to communicate with one another. - View Dependent Claims (32, 33, 34)
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35. An analyte monitoring system comprising:
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a flexible analyte sensor comprising; a base layer; a first electrode layer disposed on the base layer and including a first electrode; a first insulative layer disposed on the first electrode layer and having opposed first and second longitudinal ends, wherein said first insulative layer leaves at least a portion of the first electrode exposed through a first aperture, said first aperture being disposed longitudinally between, and away from, said first and second longitudinal ends of the first insulative layer; a second electrode layer disposed on the first insulative layer and including a second electrode; a second insulative layer disposed on the second electrode layer and having opposed first and second longitudinal ends, wherein said second insulative layer leaves at least a portion of the second electrode exposed through a second aperture, said second aperture being disposed longitudinally between, and away from, said first and second longitudinal ends of the second insulative layer; a third electrode layer disposed on the second insulative layer and including a third electrode; an enzyme layer including glucose oxidase disposed over the first, second, and third electrodes; and a glucose limiting membrane disposed over the enzyme layer, wherein the maximum height of the sensor is about 25 microns; sensor electronics in electrical communication with the first, second and third electrodes; and an analyte monitor; wherein the sensor electronics and the analyte monitor are adapted to communicate with one another. - View Dependent Claims (36, 37, 38)
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39. An analyte monitoring system comprising:
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a flexible analyte sensor comprising; a base layer; a first electrode layer disposed on the base layer and including a first electrode; a first insulative layer disposed on the first electrode layer and having opposed first and second longitudinal ends, wherein said first insulative layer leaves at least a portion of the first electrode exposed through a first aperture, said first aperture being disposed longitudinally between, and away from, said first and second longitudinal ends of the first insulative layer; a second electrode layer disposed on the first insulative layer and including a second electrode; a second insulative layer disposed on the second electrode layer and having opposed first and second longitudinal ends, wherein said second insulative layer leaves at least a portion of the second electrode exposed through a second aperture, said second aperture being disposed longitudinally between, and away from, said first and second longitudinal ends of the second insulative layer; a third electrode layer disposed on the second insulative layer and including a third electrode; and a third insulative layer disposed on the third electrode layer and having opposed first and second longitudinal ends, wherein said third insulative layer leaves at least a portion of the third electrode exposed through a third aperture, said third aperture being disposed longitudinally between, and away from, said first and second longitudinal ends of the third insulative layer, wherein the first electrode layer is disposed directly on the base layer without any intervening layers, the first insulative layer is disposed directly on the first electrode layer without any intervening layers, the second electrode layer is disposed directly on the first insulative layer without any intervening layers, the second insulative layer is disposed directly on the second electrode layer without any intervening layers, the third electrode layer is disposed directly on the second insulative layer without any intervening layers, and the third insulative layer is disposed directly on the third electrode layer without any intervening layers; and wherein the second electrode layer is directly above the first electrode layer, the third electrode layer is directly above the second electrode layer, the first, second, and third electrodes are in a staggered configuration, and the maximum height of the sensor is about 25 microns; sensor electronics in electrical communication with the first, second and third electrodes; and an analyte monitor; wherein the sensor electronics and the analyte monitor are adapted to communicate with one another. - View Dependent Claims (40)
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41. A flexible analyte sensor comprising:
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a base layer; a first electrode layer disposed on the base layer and including a first electrode; a first insulative layer disposed on the first electrode layer and having opposed first and second longitudinal ends, wherein said first insulative layer leaves at least a portion of the first electrode exposed through a first aperture, said first aperture being disposed longitudinally between, and away from, said first and second longitudinal ends of the first insulative layer; a second electrode layer disposed on the first insulative layer and including a second electrode; a second insulative layer disposed on the second electrode layer and having opposed first and second longitudinal ends, wherein said second insulative layer leaves at least a portion of the second electrode exposed through a second aperture, said second aperture being disposed longitudinally between, and away from, said first and second longitudinal ends of the second insulative layer; an enzyme layer disposed directly over said exposed portions of the electrodes; a glucose limiting membrane disposed directly over said enzyme layer; and a hydrophilic membrane disposed directly over the glucose limiting membrane, wherein the maximum height of the sensor is about 25 microns. - View Dependent Claims (42, 43, 44)
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45. An analyte monitoring system comprising:
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(a) a flexible analyte sensor comprising; a base layer; a first electrode layer disposed on the base layer and including a first electrode; a first insulative layer disposed on the first electrode layer and having opposed first and second longitudinal ends, wherein said first insulative layer leaves at least a portion of the first electrode exposed through a first aperture, said first aperture being disposed longitudinally between, and away from, said first and second longitudinal ends of the first insulative layer; a second electrode layer disposed on the first insulative layer and including a second electrode; a second insulative layer disposed on the second electrode layer and having opposed first and second longitudinal ends, wherein said second insulative layer leaves at least a portion of the second electrode exposed through a second aperture, said second aperture being disposed longitudinally between, and away from, said first and second longitudinal ends of the second insulative layer; an enzyme layer disposed directly over said exposed portions of the electrodes; a glucose limiting membrane disposed directly over said enzyme layer; and a hydrophilic membrane disposed directly over the glucose limiting membrane, wherein the second electrode layer is directly above the first electrode layer, the first and second electrodes are in a staggered configuration, and the maximum height of the sensor is about 25 microns; (b) sensor electronics in electrical communication with the first and second electrodes; and (c) an analyte monitor, wherein the sensor electronics and the analyte monitor are adapted to communicate wirelessly with one another. - View Dependent Claims (46)
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Specification