Method and apparatus for visualizing anatomical structures

• US 7,725,165 B2
• Filed: 12/07/2005
• Issued: 05/25/2010
• Est. Priority Date: 12/07/2004
• Status: Active Grant

• Current Assignee: Astute Imaging LLC
• Original Assignee: M2S, Inc. (Medstreaming, Inc.)
• Inventors: Sahin, Tuba, Chen, David
• Primary Examiner(s): Casler; Brian
• Assistant Examiner(s): MEHTA, PARIKHA SOLANKI
• Application Number:
  US11/296,103
• Publication Number:
  US 20060184006A1
• Time in Patent Office: 1,630 Days
• Field of Search: 378/42, 382/128, 382/131, 382/285, 382293-300, 600424-427, 623/1.11
• US Class Current: 600/425
• CPC Class Codes: A61B 2090/364 Correlation of different images or relation of image positions in respect to the body
• CPC Class Codes: A61B 2090/376 using X-rays, e.g. fluoroscopy
• CPC Class Codes: A61B 6/12 Arrangements for detecting or locating foreign bodies
• CPC Class Codes: A61B 6/4405 the apparatus being movable or portable, e.g. handheld or mounted on a trolley
• CPC Class Codes: A61B 6/4441 the rigid structure being a C-arm or U-arm
• CPC Class Codes: A61B 6/466 adapted to display 3D data
• CPC Class Codes: A61B 6/481 involving the use of contrast agents
• CPC Class Codes: A61B 6/504 for diagnosis of blood vessels, e.g. by angiography
• CPC Class Codes: A61B 6/5235 combining images from the same or different ionising radiation imaging techniques, e.g. PET and CT
• CPC Class Codes: A61B 90/36 Image-producing devices or illumination devices not otherwise provided for

Abstract

Apparatus and method for producing a virtual road map of a patient'"'"'s vascular anatomy comprising a virtual 3D model of the patient'"'"'s vascular and bony structure in proper registration with one another, a fluoroscope for providing real-time images of the bony structure of the patient, registration apparatus for placing the virtual 3D model in proper registration with the patient space of the fluoroscope, bone mask subtraction apparatus for generating a bone mask of the bony structure, and subtracting the same from the real-time images, whereby to create modified fluoroscope images omitting bony structure, and image generating apparatus for generating the virtual road map comprising a composite image combining (i) images of the virtual 3D structure representing the vascular structure, and (ii) modified fluoroscope images omitting bony structure, wherein the images of the virtual 3D structure representing vascular structure are in proper registration with the modified fluoroscope images omitting bony structure.

Claims

1. A method for visualizing anatomical structures, the method comprising the steps of:

(1) processing pre-acquired scanned patient-specific data so as to produce a virtual 3D model of anatomical structures of a patient, wherein processing is effected so that separate views of the patient'"'"'s bone and blood flow structures can be generated;

(2) positioning a C-arm fluoroscope with standard Anterior-Posterior (AP) orientation relative to the patient;

(3) conducting fluoroscopic imaging so as to provide real-time images of the patient'"'"'s bone structure;

(4) overlaying, on top of the fluoroscopic images, virtual images from the virtual 3D model, with those images representing only the patient'"'"'s bone structure;

(5) placing the virtual images of the patient'"'"'s bone structure generated from the virtual 3D model in registration with the fluoroscope images of the patient'"'"'s bone structure, whereby a coordinate system of the virtual 3D model is correlated to a coordinate system of the fluoroscope;

(6) imaging the patient'"'"'s bone structure using fluoroscopy so as to create a mask image of the patient'"'"'s bone structure;

(7) turning off the virtual images of the virtual bone structure and turning on the virtual images of the blood flow structure, so as to show the blood flow structure from the virtual 3D model overlaid on top of the fluoroscopic images in a semi-transparent mode, thereby providing a composite view simultaneously showing the patient'"'"'s blood flow structure from the virtual 3D model and the patient'"'"'s bone structure from the fluoroscopic images;

(8) using the mask image to subtract out the bone structure from the composite view, whereby to produce the virtual road map which will be used by the surgeon; and

(9) visualizing the virtual road map on a display monitor.

2. A method according to claim 1 wherein the pre-acquired scanned patient-specific data is obtained from apparatus selected from the group consisting of CT, CT-angiography and MRA.

3. A method according to claim 1 wherein the C-arm fluoroscope is configured to scan in a radial and an orbital direction.

4. A method according to claim 1 wherein placing the virtual images of the patient'"'"'s bone structure in registration with the fluoroscope images of the patient'"'"'s bone structure comprises manual registration.

5. A method according to claim 4 wherein manual registration comprises visually inspecting overlaid images.

6. A method according to claim 1 wherein placing the virtual images of the patient'"'"'s bone structure in registration with the fluoroscope images of the patient'"'"'s bone structure comprises semi-automatic registration.

7. A method according to claim 6 wherein semi-automatic registration comprises using landmark or fiducial points.

8. A method according to claim 1 wherein placing the virtual images of the patient'"'"'s bone structure in registration with the fluoroscope images of the patient'"'"'s bone structure comprises automatic registration of the fluoroscopic images with the virtual images of the patient'"'"'s bone structure.

9. A method according to claim 8 wherein automatic registration comprises a vision-based matching algorithm.

10. A method according to claim 9 wherein the vision-based matching algorithm comprises a Maximization of Mutual Information algorithm.

11. A method according to claim 1 wherein the C-arm fluoroscope is positioned in the abdominal area.

12. A method according to claim 1 wherein the real-time images of the patient'"'"'s bone structure comprise real-time images of the patient'"'"'s spine.