Contrast enhanced spectroscopic optical coherence tomography
First Claim
Patent Images
1. A method of forming an image of tissue, comprising:
- selecting at least one contrast agent, comprising at least one water-soluble, biocompatible absorbing agent having an absorption profile;
delivering the contrast agent to the tissue;
acquiring spectroscopic optical coherence tomography data from the tissue across a spectrum range,wherein the acquiring does not change the absorption profile of the absorbing agent; and
converting the spectroscopic optical coherence tomography data into at least one image,wherein the at least one absorbing agent absorbs in the near-infrared region,the absorption profile of the absorbing agent is sharp, andthe absorbing agent is highly absorbing in a first portion of the spectrum range and has little to no absorption in a second portion of the spectrum range.
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Abstract
A method of forming an image of a sample includes performing SOCT on a sample. The sample may include a contrast agent, which may include an absorbing agent and/or a scattering agent. A method of forming an image of tissue may include selecting a contrast agent, delivering the contrast agent to the tissue, acquiring SOCT data from the tissue, and converting the SOCT data into an image. The contributions to the SOCT data of an absorbing agent and a scattering agent in a sample may be quantified separately.
176 Citations
23 Claims
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1. A method of forming an image of tissue, comprising:
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selecting at least one contrast agent, comprising at least one water-soluble, biocompatible absorbing agent having an absorption profile; delivering the contrast agent to the tissue; acquiring spectroscopic optical coherence tomography data from the tissue across a spectrum range, wherein the acquiring does not change the absorption profile of the absorbing agent; and converting the spectroscopic optical coherence tomography data into at least one image, wherein the at least one absorbing agent absorbs in the near-infrared region, the absorption profile of the absorbing agent is sharp, and the absorbing agent is highly absorbing in a first portion of the spectrum range and has little to no absorption in a second portion of the spectrum range. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of forming an image of tissue, comprising:
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selecting a laser spectrum range that is within an optical window; selecting at least one water-soluble, biocompatible absorbing agent having an absorption profile, the absorbing agent absorbing within the laser spectrum range; selecting at least one scattering agent that scatters within the laser spectrum range; delivering the at least one absorbing agent and the at least one scattering agent to the living tissue; acquiring spectroscopic optical coherence tomography data from the living tissue across the spectrum range, wherein the acquiring does not change the absorption profile of the absorbing agent; performing time-frequency analysis on the data; performing spectral/pattern analysis on the data; retrieving the spatial distributions of the at least one absorbing agent and of the at least one scattering agent in the living tissue; and correlating the spatial distributions with at least one display parameter, wherein the at least one absorbing agent absorbs in the near-infrared region, the absorption profile of the absorbing agent is sharp, and the absorbing agent is highly absorbing in a first portion of the spectrum range and has little to no absorption in a second portion of the spectrum range.
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12. A method of converting spectroscopic optical coherence tomography data into at least one image, comprising:
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performing time-frequency analysis on spectroscopic optical coherence tomography data from tissue; performing spectral/pattern analysis on the spectroscopic optical coherence tomography data; retrieving the spatial distribution of at least one contrast agent in the tissue; and correlating the spatial distribution with at least one display parameter, wherein the at least one contrast agent comprises at least one absorbing agent having an absorption profile, the acquiring does not change the absorption profile of the absorbing agent, spectroscopic optical coherence tomography data is acquired across a spectrum range, the at least one absorbing agent absorbs in the near-infrared region, the absorption profile of the absorbing agent is sharp, and the absorbing agent is highly absorbing in a first portion of the spectrum range and has little to no absorption in a second portion of the spectrum range. - View Dependent Claims (13, 14)
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15. A method of analyzing tissue, comprising:
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delivering at least one contrast agent comprising at least one absorbing agent having an absorption profile, to the tissue; and acquiring spectroscopic optical coherence tomography data from the tissue across a spectrum range, wherein the acquiring does not change the absorption profile of the absorbing agent, the absorption profile of the absorbing agent is sharp, and the absorbing agent is highly absorbing in a first portion of the spectrum range and has little to no absorption in a second portion of the spectrum range.
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16. A method of forming an image of tissue, comprising:
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delivering at least one contrast agent comprising at least one absorbing agent having an absorption profile, to the tissue; acquiring spectroscopic optical coherence tomography data from the tissue across a spectrum range, wherein the acquiring does not change the absorption profile of the absorbing agent; separating the signal due to absorption from the signal due to scattering; and converting the spectroscopic optical coherence tomography data into at least one image, wherein the absorption profile of the absorbing agent is sharp, and the absorbing agent is highly absorbing in a first portion of the spectrum range and has little to no absorption in a second portion of the spectrum range. - View Dependent Claims (17, 18, 19, 20)
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21. A method of converting spectroscopic optical coherence tomography data into at least one image, comprising:
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performing time-frequency analysis on spectroscopic optical coherence tomography data from tissue; performing spectral/pattern analysis on the spectroscopic optical coherence tomography data; retrieving the spatial distribution of at least one contrast agent comprising at least one absorbing agent having an absorption profile, in the tissue; and correlating the spatial distribution with at least one display parameter; wherein the performing spectral/pattern analysis on the spectroscopic optical coherence tomography data comprises separating the signal due to absorption from the signal due to scattering, the spectroscopic optical coherence tomography data is acquired across a spectrum range without changing the absorption profile of the absorbing agent, the absorption profile of the absorbing agent is sharp, and the absorbing agent is highly absorbing in a first portion of the spectrum range and has little to no absorption in a second portion of the spectrum range. - View Dependent Claims (22, 23)
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Specification