Measurement of responsiveness of a subject with lowered level of consciousness

• US 7,725,173 B2
• Filed: 08/24/2005
• Issued: 05/25/2010
• Est. Priority Date: 08/24/2005
• Status: Active Grant

• Current Assignee: General Electric Company
• Original Assignee: GE Healthcare Finland OY (General Electric Company)
• Inventors: Lapinlampi, Petteri, Viertiö-Oja, Hanna E., Uutela, Kimmo
• Primary Examiner(s): Mallari; Patricia C
• Assistant Examiner(s): Toth; Karen E
• Application Number:
  US11/211,137
• Publication Number:
  US 20070055114A1
• Time in Patent Office: 1,735 Days
• Field of Search: 600/544, 600/545
• US Class Current: 600/544
• CPC Class Codes: A61B 5/377 using evoked responses
• CPC Class Codes: A61B 5/389 Electromyography [EMG]
• CPC Class Codes: A61B 5/4821 Determining level or depth of anaesthesia A61B5/1106 takes precedence
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal

Abstract

The invention relates to a method and apparatus for measuring the responsiveness of a subject with lowered level of consciousness. Physiological signal data is obtained from the subject and a first measure indicative of the level of consciousness of the subject is derived from the physiological signal data. In order to obtain an objective measure of the responsiveness of the subject and to improve the specificity of patient monitoring, a sequence of the first measure is recorded without inducing arousals in the subject and a second measure indicative of a responsiveness of the subject is determined based on the recorded sequence. The determination of the second measure may be independent of the unintentional stimuli that cause arousals in the patient or the stimuli causing such arousals in the clinical environment may be detected to find out their effect on the first measure.

Claims

1. A method for measuring the responsiveness of a subject with lowered level of consciousness, the method comprising the steps of:

obtaining physiological signal data from a subject with lowered level of consciousness;

deriving, in a computer unit, a first measure from the physiological signal data, the first measure being indicative of the level of consciousness of the subject;

recording, in a computer unit, a sequence of the first measure; and

based on the sequence, determining, in a computer unit, a second measure indicative of a responsiveness of the subject,

wherein the method is performed without inducing arousals in the subject.

2. A method according to claim 1, wherein the determining step includes the sub-steps of:

determining a third measure indicative of a change in the first measure, wherein the third measure is determined substantially at regular intervals; and

deriving the second measure from a sequence of the third measure, the sequence of the third measure containing values of the third measure determined within a first preceding time window of a predetermined length.

3. A method according to claim 2, wherein the deriving sub-step includes deriving the second measure for each third measure.

4. A method according to claim 2, wherein the determining sub-step includes finding a minimum value of the first measure from a second preceding time window of a predetermined length and deriving each value of the third measure from the difference between current value of the first measure and the minimum value found, wherein the sequence of the first measure contains the second preceding time window.

5. A method according to claim 2, wherein the deriving sub-step includes calculating a variable indicative of the sum of the sequence of the third measure.

6. A method according to claim 2, wherein the deriving sub-step includes calculating a variable indicative of the mean of the sequence of the third measure.

7. A method according to claim 6, wherein the determining sub-step includes finding a minimum value of the first measure from a second preceding time window of a predetermined length and deriving each value of the third measure as the logarithm of the difference between current value of the first measure and the minimum value found.

8. A method according to claim 2, wherein the deriving sub-step includes determining the frequency of substantial changes in the first measure within the first preceding time window.

9. A method according to claim 2, wherein the deriving sub-step includes determining the total number of substantial changes in the first measure within the first preceding time window.

10. A method according to claim 1, wherein

the obtaining step includes obtaining EEG signal data from the subject;

and

the deriving step includes deriving the first measure, in which the first measure is indicative of power in a high-frequency band of the EEG signal data.

11. A method according to claim 1, wherein

the obtaining step includes obtaining EEG signal data from the subject;

and

the deriving step includes deriving the first measure, in which the first measure is indicative of an entropy of the EEG signal data.

12. A method according to claim 1, wherein

the obtaining step includes obtaining EEG signal data from the subject;

and

the deriving step includes deriving the first measure, in which the first measure is indicative of the Bispectral Index (BIS™

) of the EEG signal data.

13. A method according to claim 1, wherein

the obtaining step includes obtaining EMG signal data from the subject;

and

the deriving step includes deriving the first measure, in which the first measure is indicative of power of the EMG signal data.

14. A method according to claim 1, further comprising a step of detecting a stimulus produced by at least one predetermined stimulus source.

15. A method according to claim 14, wherein the detecting step includes measuring noise level.

16. A method according to claim 14, wherein the detecting step includes detecting a predetermined clinical procedure.

17. A method according to claim 14, wherein the detecting step includes measuring an intensity of the stimulus.

18. A method according to claim 14, wherein determining step includes the sub-steps of:

measuring a change caused by the stimulus in the first measure, wherein the stimulus is produced by at least one of the at least one predetermined stimulus source; and

determining the second measure based on the change measured.

19. A method according to claim 14, wherein the determining step includes the sub-steps of:

measuring changes caused by a plurality of stimuli in the first measure, wherein the plurality of stimuli is produced by at least one of the at least one predetermined stimulus source; and

determining the second measure based on the changes measured.

20. A method according to claim 19, wherein the measuring sub-step includes measuring the changes over a time period, the length of the time period being measured in a predetermined manner.

21. A method according to claim 19, wherein determining sub-step includes defining the mean value of the changes measured.