Catheter with multiple ultrasound radiating members

• US 7,727,178 B2
• Filed: 12/21/2006
• Issued: 06/01/2010
• Est. Priority Date: 12/03/2001
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: EKOS Corporation (Boston Scientific Corporation)
• Inventors: Wilson, Richard R., Cohen, Amy, Genstler, Curtis, Wilcox, Robert L., Peskin, Natalya, Oliver, Leonard R., Keilman, George, Barrere, Wm. Gerrit, Abrahamson, Tim
• Primary Examiner(s): Mendez; Manuel A
• Application Number:
  US11/643,471
• Publication Number:
  US 20070112296A1
• Time in Patent Office: 1,258 Days
• Field of Search: 604 19- 22, 600437-472, 736/25, 736/26, 601/2, 601/3, 607/22
• US Class Current: 604/22
• CPC Class Codes: A61B 17/2202 the ultrasound transducer being inside patient's body at the distal end of the catheter
• CPC Class Codes: A61B 2017/22084 stone- or thrombus-dissolving
• CPC Class Codes: A61B 2017/22088 ultrasound absorbing, drug activated by ultrasound
• CPC Class Codes: A61M 25/0029 characterized by features relating to least one lumen located at the middle part of the catheter, e.g. slots, flaps, valves, cuffs, apertures, notches, grooves or rapid exchange ports catheter shaft surface irregularities A61M2025/006
• CPC Class Codes: A61M 25/0032 characterized by at least one unconventionally shaped lumen, e.g. polygons, ellipsoids, wedges or shapes comprising concave and convex parts
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

A catheter for delivering ultrasonic energy and therapeutic compounds to a treatment site within a patient'"'"'s vasculature comprises a tubular body. The tubular body has a proximal region and a distal region opposite the proximal region. The catheter further comprises a plurality of fluid delivery lumens formed into the tubular body. The catheter further comprises an inner core configured for insertion into the tubular body. The inner core comprises an elongate electrical conductor having a plurality of flattened regions, each flattened region having a first flat side and a second flat side opposite the first flat side. The inner core further comprises a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor. A first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor. The catheter further comprises control electronics configured to apply a driving signal to at least two, but fewer than all, of the ultrasound radiating members.

Claims

1. A catheter system for delivering ultrasonic energy and a therapeutic compound to a treatment site within a body lumen, the catheter comprising:

a tubular body having a proximal end, a distal end and an energy delivery section positioned between the proximal end and the distal end;

a fluid delivery lumen extending at least partially through the tubular body and having at least one outlet in the energy delivery section; and

an inner core configured for insertion into the tubular body, the inner core comprising;

an elongate electrical conductor having a plurality of flattened regions, each flattened region having a first flat side and a second flat side opposite the first flat side, and

a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor, such that a first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor; and

wiring such that a voltage can be applied from the elongate electrical conductor across the first and second ultrasound radiating members such that the first and second ultrasound radiating members can be driven simultaneously.

2. The catheter system of claim 1, wherein the fluid delivery lumen comprises a plurality of lumens formed within the tubular body.

3. The catheter system of claim 2, wherein the fluid delivery lumen comprises three lumens.

4. The catheter system of claim 3, wherein the three fluid delivery lumens are equally spaced approximately 120 degrees apart from each other around a central axis of the tubular body.

5. The catheter system of claim 1, further comprising a cooling fluid lumen defined at least in part by an inner surface of the tubular body and an outer surface of the inner core.

6. The catheter system of claim 1, wherein the catheter system further comprises a plurality of cooling fluid lumens, each cooling fluid lumen being defined at least in part by an inner surface of the tubular body and an outer surface of the inner core.

7. The catheter system of claim 6, wherein the catheter system includes three cooling fluid lumens that are equally spaced approximately 120 degrees apart from each other about a central axis of the tubular body.

8. The catheter system of claim 1, wherein the plurality of ultrasound radiating members are electrically coupled into a plurality of electrical groups, each group of ultrasound radiating members independently drivable by a control system.

9. The catheter system of claim 8, wherein each member of an electrical group is spatially grouped together.

10. The catheter system of claim 8, wherein each member of an electrical group is positioned adjacent to at least one other member of the electrical group.

11. The catheter of claim 8, wherein the ultrasound radiating members are allocated into five electrical groups.

12. The catheter of claim 11, wherein each electrical group comprises twelve ultrasound radiating members.

13. The catheter of claim 1, wherein the ultrasonic radiating members are ultrasonic transducers in the shape of a rectangular bar.

14. An ultrasonic catheter comprising:

a tubular body having a proximal end, a distal end and a treatment zone located between the distal end and the proximal end;

a plurality of fluid delivery lumens defined within the tubular body;

an inner core comprising at least one ultrasound radiating element; and

a plurality of cooling fluid channels defined between at least an inner surface of the tubular body and an outer surface of the inner core, each cooling fluid channel being positioned generally radially between two fluid delivery lumens.

15. The ultrasonic catheter of claim 14, wherein the catheter includes three fluid delivery lumens.

16. The ultrasonic catheter of claim 15, wherein the catheter includes three cooling fluid channels.

17. The ultrasonic catheter of claim 15, wherein the three fluid delivery lumens spaced approximately 120 degrees radially apart from each other.

18. The ultrasonic catheter of claim 14, wherein the inner core further comprises an elongate electrical conductor having at least one flattened region, wherein the ultrasound radiating element is mounted to the flattened region.

19. The ultrasonic catheter of claim 14, wherein the inner core further comprises a plurality of elongate electrical conductors configured to apply a voltage across the ultrasound radiating element.

20. The ultrasonic catheter of claim 14, further comprising a plurality of ultrasound radiating elements, wherein the plurality of ultrasound radiating elements are electrically coupled into a plurality of electrical groups, each group of ultrasound radiating elements independently drivable by a control system.

21. The ultrasonic catheter of claim 14, wherein the ultrasonic radiating element is an ultrasonic transducer in the shape of a rectangular bar.

22. The ultrasonic catheter of claim 14, wherein the treatment zone has a greater acoustic transparency than a region of the tubular body proximal to the treatment zone.

23. The ultrasonic catheter of claim 14, wherein the inner core can be removably inserted into the tubular body so as to position the ultrasonic radiating element in the treatment zone.