Biological revascularization

• US 7,727,184 B2
• Filed: 05/17/2007
• Issued: 06/01/2010
• Est. Priority Date: 09/13/2000
• Status: Expired due to Term

• Current Assignee: Mayo Foundation For Medical Education And Research (Mayo Clinic)
• Original Assignee: Mayo Foundation For Medical Education And Research (Mayo Clinic)
• Inventors: Schwartz, Robert S., Holmes, David R. Jr.
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): CHANDER, DIVA KAKAR
• Application Number:
  US11/750,131
• Publication Number:
  US 20070270740A1
• Time in Patent Office: 1,111 Days
• Field of Search: 604/93.01
• US Class Current: 604/93.01
• CPC Class Codes: A61B 17/22 Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for dilators A61M29/00
• CPC Class Codes: A61B 17/3207 Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions A61B17/32037 takes precedence; endoscopic cutting instruments A61B17/320016
• CPC Class Codes: A61B 18/1477 Needle-like probes
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2017/00252 for by-pass connections, i.e. connections from heart chamber to blood vessel or from blood vessel to blood vessel
• CPC Class Codes: A61B 2017/22044 with a pointed tip
• CPC Class Codes: A61B 2017/22067 Blocking; Occlusion A61B2017/22054 takes precedence
• CPC Class Codes: A61B 2017/22077 with a part piercing the tissue A61B2017/22044 takes precedence
• CPC Class Codes: A61B 2017/22082 after introduction of a substance
• CPC Class Codes: A61B 2017/22084 stone- or thrombus-dissolving
• CPC Class Codes: A61B 2018/1425 Needle

Abstract

A catheter delivery system for delivering a treatment substance to an occlusion in a lumen of a tubular vessel includes a tubular catheter and a treatment substance. The tubular catheter includes a central lumen passing between a proximal end and a distal end adjacent to an inflatable balloon. The treatment substance is in a form that is configured to be deliverable through the central lumen of the catheter into the lumen of the tubular vessel and to solidify in the vessel.

Claims

1. A method of delivering a treatment substance to a chronic total occlusion, the method comprising:

(a) providing a tubular catheter having a lumen passing between a proximal end and a distal end;

(b) providing a treatment substance comprising an angiogenesis agent or an occlusion dissolving agent for delivery through the tubular catheter to a position adjacent the occlusion;

(c) inserting the tubular catheter into a mammalian vasculature;

(d) advancing the tubular catheter through the vasculature until the distal end of the tubular catheter is adjacent to the chronic total occlusion; and

(e) injecting the treatment substance through the tubular catheter to the position adjacent the chronic total occlusion.

2. The method of claim 1, wherein the treatment substance comprises an angiogenesis agent.

3. The method of claim 1, wherein the treatment substance comprises an occlusion dissolving agent.

4. The method of claim 1, wherein the treatment substance comprises an inflammatory agent.

5. The method of claim 1, wherein the treatment substance comprises a biodegradable material.

6. The method of claim 1, wherein the tubular catheter includes a distal end having a tapered tip.

7. The method of claim 6, wherein the tapered tip has at least one eye hole passing through a wall of the tubular catheter.

8. The method of claim 1, wherein step (e) results in the formation of a plug that abuts the chronic total occlusion.

9. The method of claim 8, wherein the plug degrades over time.