Device for monitoring a patient for a urinary tract infection

• US 7,727,206 B2
• Filed: 12/27/2005
• Issued: 06/01/2010
• Est. Priority Date: 12/27/2005
• Status: Active Grant

• Current Assignee: Geoffrey H. Gorres
• Original Assignee: Geoffrey H. Gorres
• Inventors: Gorres, Geoffrey H.
• Primary Examiner(s): Deak; Leslie R
• Assistant Examiner(s): MARCETICH, ADAM M
• Application Number:
  US11/318,769
• Publication Number:
  US 20070148716A1
• Time in Patent Office: 1,617 Days
• Field of Search: 604/317, 604/318, 604/319, 604/327, 604/328, 604/329, 604/330, 604/544, 604/3, 604/6.15, 604/100.01, 604/100.02, 604/110, 604/111, 604/168.01, 604/181, 604/322, 604/326, 604/408, 604/48, 604/500, 604/82, 604/93.01, 435/4, 435/7.1, 435/7.4, 435/7.9, 435/12, 435/286.2, 435/287.1, 435/287.7, 435/287.8, 435/287.9, 435/288.2, 435/288.4, 435/288.5, 435/810, 435/975, 422/55, 422/56, 422/57, 422/58, 422/61, 422/68.1, 422/99, 422/187, 422/214, 436/164, 436/810, 128/DIG.25
• US Class Current: 604/349
• CPC Class Codes: C12Q 1/04 Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor C12Q1/6897 takes precedence
• CPC Class Codes: G01N 33/54366 Apparatus specially adapted for solid-phase testing
• CPC Class Codes: G01N 33/569 for microorganisms, e.g. protozoa, bacteria, viruses
• CPC Class Codes: Y10S 435/81 Packaged device or kit
• CPC Class Codes: Y10S 435/975 Kit
• CPC Class Codes: Y10S 436/81 Tube, bottle, or dipstick

Abstract

The invention provides for a urinary monitoring device to monitor for the presence or absence of markers indicative of a urinary tract infection (UTI). The invention also provides for methods of using such a device.

Claims

1. A urinary tract infection (UTI)-monitoring urinary catheter system for monitoring the presence or absence of one or more markers in urine that are indicative of a urinary tract infection (UTI) comprising a catheter portion, a collection tubing portion, and a collection bag portion, wherein said collection tubing portion further comprises multiple UTI indicator substrates, wherein said multiple UTI indicator substrates are configured to be serially exposed to multiple freshly voided urine specimens along said collection tubing portion, wherein said multiple UTI indicator substrates are sequestered from one another and from the urine but, when exposed to a freshly voided urine specimen, are capable of detecting and signaling the presence or absence of one or more markers in said freshly voided urine specimen that are indicative of a UTI.

2. The UTI-monitoring urinary catheter system of claim 1, wherein said UTI indicator substrate is separately and sequentially exposed to urine inside of said collection tubing portion.

3. The UTI-monitoring urinary catheter system of claim 1, wherein said multiple UTI indicator substrates are releasably attached to an inside surface of said collection tubing portion.

4. The UTI-monitoring urinary catheter system of claim 1, wherein each of said multiple UTI indicator substrates detects leukocyte esterase.

5. The UTI-monitoring urinary catheter system of claim 4, wherein each of said multiple UTI indicator substrates further detects nitrites.

6. The UTI-monitoring urinary catheter system of claim 1, wherein at least one of said multiple UTI indicator substrates detects nitrites.

7. The UTI-monitoring urinary catheter system of claim 1, wherein the UTI indicator substrate comprises an antibody that has a specific binding affinity for said one or more markers in urine that are indicative of a UTI.

8. The UTI-monitoring urinary catheter system of claim 1, wherein the presence of one or more markers in said freshly voided urine is indicated by a colorimetric change.

9. A UTI monitoring device for monitoring the presence or absence of one or more markers in urine that are indicative of a urinary tract infection comprising

a first port on one end and a second port on the other end, wherein said first and second ports are configured for in-line placement within a collection tubing portion of a urinary catheter, wherein, located between said first and second ports are multiple UTI indicator substrates, wherein said multiple UTI indicator substrates are configured to be serially exposed to multiple freshly voided urine specimens, wherein said multiple UTI indicator substrates are sequestered from one another and from the urine but, when exposed to a freshly voided urine specimen, can detect and signal the presence or absence of said one or more markers in said freshly voided urine specimen that are indicative of a UTI.

10. A method for monitoring a catheterized patient'"'"'s urine for the presence or absence of one or more markers indicative of a UTI comprising catheterizing a patient with a urinary catheter system comprising multiple UTI indicator substrates, wherein said multiple UTI indicator substrates are configured to be serially exposed to multiple freshly voided urine specimens along a collection tubing portion, wherein said multiple UTI indicator substrates are sequestered from one another and from the urine but, when exposed to a freshly voided urine specimen, are capable of detecting and signaling the presence or absence of one or more markers in said freshly voided urine specimen that are indicative of a UTI, exposing at least one of said UTI indicator substrates to a freshly voided urine specimen, and monitoring said exposed UTI indicator substrate to observe whether it signals the presence or absence of said one or more markers indicative of a UTI.