Methods for diagnosis using anti-cytokine receptor antibodies
First Claim
1. A method for diagnosing inflammation or cancer comprising administering to a patient, effective amount of antibody or antibody fragments binding to soluble tumor necrosis factor receptor 1 (“
- TNFR1”
) or tumor necrosis factor 2 (“
TNFR2”
), to bind the circulating soluble receptor, thenadministering an effective amount of a labeled antibody binding to the tumor necrosis factor receptor to bind the tumor necrosis factor receptor on the surface of tumor cells and in the tumor microenvironment, andimaging the patient to detect labeled antibody bound to the tumor necrosis factor receptor on the surface of the tumor cells and in the tumor microenvironment.
1 Assignment
0 Petitions
Accused Products
Abstract
Labeled antibodies, antibody fragments or peptides binding to soluble cytokines or cytokine receptors are used to diagnose whether a patient has cancer or an autoimmune disease. In a preferred embodiment, a radiolabelled tag that is chemically bound to a peptide, antibody, or antibody fragment specific for sTNFR-1 and/or sTNFR2 is injected into a patient with a tumor, or suspected tumor, or with any disease associated with STNF-1/STNF-2. The patient is then imaged using standard nuclear imaging equipment to detect areas or sites of concentration of the radiolabel and/or receptor/inhibitor and/or antigen. By screening for cancer by the substances it produces, using an injected antibody to that substance with a tracer attached to it, one can detect cancer at a very early stage, potentially even microscopically.
62 Citations
11 Claims
-
1. A method for diagnosing inflammation or cancer comprising administering to a patient, effective amount of antibody or antibody fragments binding to soluble tumor necrosis factor receptor 1 (“
- TNFR1”
) or tumor necrosis factor 2 (“
TNFR2”
), to bind the circulating soluble receptor, thenadministering an effective amount of a labeled antibody binding to the tumor necrosis factor receptor to bind the tumor necrosis factor receptor on the surface of tumor cells and in the tumor microenvironment, and imaging the patient to detect labeled antibody bound to the tumor necrosis factor receptor on the surface of the tumor cells and in the tumor microenvironment. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
- TNFR1”
Specification