Controlled release nanoparticle having bound oligonucleotide for targeted delivery
First Claim
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1. A controlled release polymer nanoparticle, comprising:
- a therapeutic or diagnostic agent incorporated in the controlled release polymer nanoparticle;
a nucleic acid ligand comprising an oligonucleotide bound to the surface of the controlled release polymer nanoparticle that selectively binds to a target cell or tissue, and thereby delivers the controlled release polymer nanoparticle to the target cell or tissue;
wherein the controlled release polymer nanoparticle carries a neutral to negative charge on its surface, wherein the bound oligonucleotide has a folded three-dimensional conformation resulting from intramolecular interactions; and
wherein the nucleic acid ligand is an aptamer.
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Abstract
The present invention relates to a conjugate that includes a nucleic acid ligand bound to a controlled release polymer system, a pharmaceutical composition that contains the conjugate, and methods of treatment using the conjugate. The controlled release polymer system includes an agent such as a therapeutic, diagnostic, prognostic, or prophylactic agent. The nucleic acid ligand that is bound to the controlled release polymer system, binds selectively to a target, such as a cell surface antigen, and thereby delivers the controlled release polymer system to the target.
238 Citations
23 Claims
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1. A controlled release polymer nanoparticle, comprising:
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a therapeutic or diagnostic agent incorporated in the controlled release polymer nanoparticle; a nucleic acid ligand comprising an oligonucleotide bound to the surface of the controlled release polymer nanoparticle that selectively binds to a target cell or tissue, and thereby delivers the controlled release polymer nanoparticle to the target cell or tissue; wherein the controlled release polymer nanoparticle carries a neutral to negative charge on its surface, wherein the bound oligonucleotide has a folded three-dimensional conformation resulting from intramolecular interactions; and wherein the nucleic acid ligand is an aptamer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 22, 23)
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20. A controlled release polymer nanoparticle, comprising;
- a therapeutic or diagnostic agent incorporated in the controlled release polymer nanoparticle; and
a nucleic acid ligand comprising an oligonucleotide bound to the surface of the controlled release polymer nanoparticle that selectively binds to a target cell or tissue, and thereby delivers the controlled release polymer nanoparticle to the target cell or tissue;
wherein the controlled release polymer nanoparticle carries a neutral to negative charge on its surface; and
wherein the bound oligonucleotide has a folded three-dimensional conformation resulting from intramolecular interactions;
wherein the nucleic acid ligand binds to an antigen.
- a therapeutic or diagnostic agent incorporated in the controlled release polymer nanoparticle; and
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21. A controlled release polymer nanoparticle, comprising;
- a therapeutic or diagnostic agent incorporated in the controlled release polymer nanoparticle; and
a nucleic acid ligand comprising an oligonucleotide bound to the surface of the controlled release polymer nanoparticle that selectively binds to a target cell or tissue, and thereby delivers the controlled release polymer nanoparticle to the target cell or tissue;
wherein the controlled release polymer nanoparticle carries a neutral to negative charge on its surface; and
wherein the bound oligonucleotide has a folded three-dimensional conformation resulting from intramolecular interactions;
wherein the therapeutic agent is a protein drug selected from the group consisting of an antibody, an antibody fragment, a recombinant antibody, a recombinant protein, a purified protein, a peptide, an amino acid and combinations thereof.
- a therapeutic or diagnostic agent incorporated in the controlled release polymer nanoparticle; and
Specification