Stabilized interferon liquid formulations
First Claim
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1. A composition comprising:
- a) about 88 μ
g/ml interferon-beta 1ab) about 27.3 mg/ml lysine;
c) about 0.12 mg/ml methionine;
d) about 0.5 mg/ml poloxomer 188; and
c) an aqueous acetate buffer at a pH of 3.5 to 5.5.
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Abstract
A stabilized HSA-free liquid pharmaceutical composition is described, which comprises an interferon (IFN), wherein said formulation is a solution that comprises a buffer, an amino acid and an antioxidant. Preferably, the interferon is human recombinant IFN-beta.
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Citations
2 Claims
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1. A composition comprising:
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a) about 88 μ
g/ml interferon-beta 1ab) about 27.3 mg/ml lysine; c) about 0.12 mg/ml methionine; d) about 0.5 mg/ml poloxomer 188; and c) an aqueous acetate buffer at a pH of 3.5 to 5.5.
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2. A composition comprising interferon-beta 1a, lysine, methionine and poloxomer 188 in an aqueous acetate buffer having a pH of about 3.4 to 5.5, said composition containing interferon-beta 1a, lysine, methionine and poloxomer 188 at a ratio of interferon-beta 1a:
- lysine;
methionine;
poloxomer 188 of about;
1;
310;
1.4;
5.7.
- lysine;
Specification