Compositions for treating amyloid associated diseases

• US 7,732,479 B2
• Filed: 08/18/2005
• Issued: 06/08/2010
• Est. Priority Date: 08/19/2004
• Status: Expired due to Fees

• Current Assignee: Tel Aviv University Future Technology Development L.P. (Tel Aviv University)
• Original Assignee: Tel Aviv University Future Technology Development L.P. (Tel Aviv University)
• Inventors: Cohen, Tomer, Gazit, Ehud
• Primary Examiner(s): Marschel; Ardin
• Assistant Examiner(s): RAO, SAVITHA M
• Application Number:
  US11/660,522
• Publication Number:
  US 20080194667A1
• Time in Patent Office: 1,755 Days
• Field of Search: 514/415, 514/416, 514/418, 514/419, 514/493
• US Class Current: 514/415
• CPC Class Codes: A61K 31/403 condensed with carbocyclic rings, e.g. carbazole
• CPC Class Codes: A61K 31/404 Indoles, e.g. pindolol
• CPC Class Codes: A61K 31/415 1,2-Diazoles
• CPC Class Codes: A61K 31/4164 1,3-Diazoles
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 5/50 for increasing or potentiating the activity of insulin
• CPC Class Codes: C07D 209/12 Radicals substituted by oxygen atoms
• CPC Class Codes: C07D 209/32 Oxygen atoms

Abstract

Indole derivatives, compositions including same, and methods utilizing same for the treatment of amyloid associated diseases, such as type II diabetes mellitus, Alzheimer'"'"'s dementia or diseases, systemic and localized amyloidosis, and prion-related encephalopathies are provided.

Claims

1. A method of treating Alzheimer'"'"'s disease in a subject, the method comprising administering to a subject in need thereof, a therapeutically effective amount of a compound selected from the group consisting of 3-hydroxyindole and 4-hydroxyindole and

thereby treating the Alzheimer'"'"'s disease in the subject.