Method and apparatus for gastrointestinal stimulation via the lymphatic system

• US 7,734,341 B2
• Filed: 06/06/2006
• Issued: 06/08/2010
• Est. Priority Date: 06/06/2006
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Shuros, Allan C.
• Primary Examiner(s): Evanisko; George R
• Assistant Examiner(s): KAHELIN, MICHAEL WILLIAM
• Application Number:
  US11/422,418
• Publication Number:
  US 20070282386A1
• Time in Patent Office: 1,463 Days
• Field of Search: 607/40, 607/2
• US Class Current: 607/2
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control

Abstract

An implantable gastrointestinal (GI) stimulation system includes an implantable medical device and at least one stimulus delivery device configured to be placed in one or more lymphatic vessels of a patient, such as the patient'"'"'s thoracic duct and/or vessels branching from the thoracic duct. In one embodiment, the implantable medical device includes a GI stimulation circuit to deliver electrical stimulation pulses to one or more target regions adjacent to a lymphatic vessel through the stimulus delivery device. In one embodiment, to control obesity, the electrical stimulation pulses are delivered to the organs and/or nerves of the GI tract to create a sensation of satiety and/or to expedite food movement through the GI tract.

Claims

1. A method for delivering stimulation to a body having lymphatic vessels and a gastrointestinal (GI) tract, the lymphatic vessels including a thoracic duct and vessels branching from the thoracic duct, the GI tract including GI organs and nerves innervating the GI organs, the method comprising:

delivering GI stimuli to one or more of the GI organs and the nerves innervating the GI organs from an implantable medical device through at least a first stimulation electrode placed in a lymphatic vessel of the thoracic duct and the lymphatic vessels branching from the thoracic duct.

2. The method of claim 1, further comprising altering a natural path of the lymphatic vessel to cause a portion of the lymphatic vessel to contact a target region to which the GI stimuli are delivered using an electrode base configured to be implanted in the lymphatic vessel, and wherein the first stimulation electrode is incorporated into or integrated with the electrode base.

3. The method of claim 1, wherein delivering the GI stimuli comprises delivering the GI stimuli through a stimulation electrode placed in the thoracic duct.

4. The method of claim 1, wherein delivering the GI stimuli comprises delivering the GI stimuli through a stimulation electrode placed in one of the vessels branching from the thoracic duct.

5. The method of claim 1, wherein delivering the GI stimuli comprises delivering the GI stimuli through the first stimulation electrode and a second stimulation electrode placed in the lymphatic vessel.

6. The method of claim 1, wherein delivering the GI stimuli comprises delivering the GI stimuli through the first stimulation electrode and a second stimulation electrode placed in a location external to the lymphatic vessels.

7. The method of claim 1, further comprising:

sensing one or more physiological signals; and

controlling the delivery of the GI stimuli using the one or more physiological signals.

8. The method of claim 1, further comprising programming the implantable medical device with one or more stimulation parameters to cause the GI stimuli to create a sensation discouraging food consumption.

9. The method of claim 8, further comprising programming the implantable medical device with one or more stimulation parameters to cause the GI stimuli to create a sensation of satiety.

10. The method of claim 9, further comprising programming the implantable medical device with one or more stimulation parameters to cause the GI stimuli to increase motor activities in the GI tract.

11. The method of claim 2, wherein using the electrode base comprises using an elongate electrode base including one or more biases each configured to alter the natural path of the lymphatic vessel to cause the portion of the lymphatic vessel to contact the target region.

12. The method of claim 2, wherein using the electrode base comprises using an expandable electrode.

13. The method of claim 12, wherein using the electrode base comprises using a stent.

14. The method of claim 7, wherein controlling the delivery of the GI stimuli using the one or more physiological signals comprises using a physiological signal of the one or more physiological signals as a feedback signal to provide closed-loop GI stimulation.

15. The method of claim 7, wherein sensing the one or more physiological signals comprises sensing a physiological signal of the one or more physiological signals using the first stimulation electrode.

16. The method of claim 15, wherein sensing the one or more physiological signals comprises sensing a neural signal.

17. The method of claim 15, wherein sensing the one or more physiological signals comprises sensing an electromyographic signal.

18. The method of claim 7, wherein sensing the one or more physiological signals comprises sensing one or more signals each indicative of a physiological function regulated by the delivering the GI stimuli.

19. The method of claim 7, comprising:

sensing a biopotential signal indicative of ongoing food consumption; and

controlling the delivering the GI stimuli to augment a sensation of satiety when the sensed biopotential indicates the ongoing food consumption.

20. The method of claim 1, comprising:

sensing a biopotential signal indicative of ongoing food consumption and digestion; and

controlling the delivering the GI stimuli to increase motor activities in the GI tract when the sensed biopotential indicates the ongoing food consumption and digestion.