Treatment of disorders by unidirectional nerve stimulation

• US 7,734,355 B2
• Filed: 01/23/2002
• Issued: 06/08/2010
• Est. Priority Date: 08/31/2001
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: BioControl Medical (B.C.M) Ltd.
• Inventors: Cohen, Ehud, Gross, Yossi, Ayal, Shai
• Primary Examiner(s): BOCKELMAN, MARK
• Application Number:
  US10/488,334
• Publication Number:
  US 20040243182A1
• Time in Patent Office: 3,058 Days
• Field of Search: 607/9, 607/39, 607/42, 607 44- 49, 607/2, 607/40, 607/118
• US Class Current: 607/118
• CPC Class Codes: A61N 1/0556 Cuff electrodes
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362

Abstract

Apparatus (18) for treating a condition of a subject is provided. An electrode device (100) is adapted to be coupled to longitudinal nervous tissue (40) of the subject, and a control unit (50) is adapted to drive the electrode device to apply to the nervous tissue a current which is capable of inducing action potentials that propagate in the nervous tissue in a first direction, so as to treat the condition. The control unit is further adapted to suppress action potentials from propagating in the nervous tissue in a second direction opposite to the first direction.

Claims

1. A method for treating a condition of a subject, comprising:

driving into longitudinal nervous tissue of the subject a stimulating current at a first longitudinal location which is capable of inducing action potentials that propagate in the nervous tissue in a first direction which action potentials include slower and faster action potentials; and

suppressing the slower action potentials from propagating in the nervous tissue in the first direction by applying a blocking current at a second longitudinal location after a delay following driving the stimulating current, and timing the delay to allow passage of the faster action potentials, while suppressing the slower action potentials,

wherein the longitudinal nervous tissue includes at least one nerve selected from the group consisting of;

a sympathetic nerve of the subject, and a parasympathetic nerve of the subject.

2. A method according to claim 1, wherein driving the stimulating and blocking currents comprises driving the stimulating and blocking currents into tissue selected from the group consisting of:

a pudendal nerve of the subject, a cavernous nerve of the subject, a spinal nerve root of the subject, and a cervical nerve of the subject.

3. A method according to claim 1, wherein driving the stimulating and blocking currents comprises driving stimulating and blocking currents into the parasympathetic nerve of the subject.

4. A method according to claim 3, wherein driving the stimulating and blocking currents comprises driving the stimulating and blocking currents into a nerve of the subject that provides parasympathetic innervation to a heart of the subject.

5. A method according to claim 1, wherein driving the stimulating and blocking currents comprises driving the stimulating and blocking currents into at least one nerve of the subject selected from the group consisting of:

(a) a nerve of the subject that provides sympathetic innervation to a lung of the subject, and

(b) a nerve of the subject that provides parasympathetic innervation to a lung of the subject, and

(c) a nerve that modulates hidrosis of the subject.

6. A method according to claim 1, wherein driving the stimulating and blocking currents comprises at least one of the group consisting of:

(a) configuring the currents to be capable of treating muscle spasm of the subject, and

(b) configuring the currents to be capable of treating vaginismus of the subject.

7. A method according to claim 1, wherein driving the stimulating and blocking currents comprises configuring the stimulating and blocking currents to be capable of treating an aspect of heart failure of the subject.

8. A method according to claim 1, wherein driving the stimulating and blocking currents comprises configuring the stimulating and blocking currents to be capable of treating an aspect of cardiac arrhythmia of the subject.

9. A method according to claim 1, wherein driving the stimulating and blocking currents comprises configuring the stimulating and blocking currents to be capable of treating tachycardia of the subject.

10. A method according to claim 1, wherein driving the stimulating and blocking currents comprises configuring the stimulating and blocking currents to be capable of treating bradycardia of the subject.

11. A method according to claim 1, wherein driving the stimulating and blocking currents comprises configuring the stimulating and blocking currents to be capable of treating an aspect of chronic obstructive pulmonary disorder (COPD) of the subject.

12. A method according to claim 1, and comprising implanting electrodes in a vicinity of the nervous tissue, wherein driving the stimulating and blocking currents comprises driving the stimulating and blocking currents through the electrodes on a chronic basis.

13. A method according to claim 1, and comprising placing electrodes in a vicinity of the nervous tissue in response to an acute occurrence, wherein driving the stimulating and blocking currents comprises driving the stimulating and blocking currents through the electrodes, and wherein the method comprises removing the electrodes following the acute occurrence.

14. A method according to claim 1, wherein driving the stimulating and blocking currents comprises configuring the stimulating and blocking currents so as to induce action potential propagation primarily in A fibers of the nervous tissue.

15. A method according to claim 1, wherein driving the stimulating and blocking currents comprises driving the stimulating and blocking currents into the sympathetic nerve of the subject.

16. A method according to claim 15, wherein driving the stimulating and blocking currents comprises driving the stimulating and blocking currents into a nerve of the subject that provides sympathetic innervation to a heart of the subject.

17. A method according to claim 1, wherein suppressing the slower action potentials comprises configuring the blocking current to eliminate, by collision blocking, the slower action potentials propagating in the second direction.

18. A method according to claim 1, wherein the delay has a duration of 200 microseconds.