Anti-inflammatory medicaments

• US 7,737,283 B2
• Filed: 06/09/2006
• Issued: 06/15/2010
• Est. Priority Date: 12/31/2002
• Status: Expired due to Fees

• Current Assignee: Deciphera Pharmaceuticals, LLC (Deciphera Pharmaceuticals, Inc.)
• Original Assignee: Deciphera Pharmaceuticals, LLC (Deciphera Pharmaceuticals, Inc.)
• Inventors: Flynn, Daniel L., Petillo, Peter A.
• Primary Examiner(s): Saeed; Kamal A
• Assistant Examiner(s): Shterengarts; Samantha L
• Application Number:
  US11/450,849
• Publication Number:
  US 20090075986A1
• Time in Patent Office: 1,467 Days
• Field of Search: 548/134, 548/135, 548/300.1, 548/311.1, 548/315.7, 514/361, 514/362, 514/385, 514/386, 435/188
• US Class Current: 548/135
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 11/16 Central respiratory analeptics
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/06 Antigout agents, e.g. antihyperuricemic or uricosuric agents
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/00 Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: A61P 7/06 Antianaemics
• CPC Class Codes: A61P 9/08 Vasodilators for multiple indications
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07D 239/42 One nitrogen atom nitro radicals C07D239/30
• CPC Class Codes: C07D 295/10 substituted by doubly bound oxygen or sulphur atoms
• CPC Class Codes: C07D 401/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 403/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 413/12 : linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 413/14 : containing three or more hetero rings
• CPC Class Codes: C07D 417/12 : linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 417/14 : containing three or more hetero rings

Abstract

Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kinase protein with the novel compounds.

Claims

1. A compound having the formula

2. The compound of claim 1, wherein A is phenyl substituted by one or more R₇′

substituents, said R₇′

substituents being halogens.

3. The compound of claim 1, wherein A is an R₇′

-substituted naphthyl.

4. The compound of claim 1, where R₇″

is selected from the group consisting of aryls and heterocyclyls.

5. The compound of claim 1, wherein A is an R₇′

-substituted naphthyl.

6. The compound of claim 1, where R₇″

is selected from the group consisting of aryls and heterocyclyls.

7. An adduct comprising a molecule bound with a kinase, said molecule having the formula

8. The adduct of claim 7, wherein A is phenyl substituted by one or more R₇′

substituents, said R₇′

substituents being halogens.

9. The adduct of claim 7, wherein A is an R₇′

-substituted naphthyl.

10. The adduct of claim 7, where R₇″

is selected from the group consisting of aryls and heterocyclyls.