Methods and devices for reduction of motion-induced noise in pulse oximetry

• US 7,738,935 B1
• Filed: 12/12/2005
• Issued: 06/15/2010
• Est. Priority Date: 07/09/2002
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Turcott, Robert G.
• Primary Examiner(s): Winakur; Eric F
• Assistant Examiner(s): Berhanu; Etsub D
• Application Number:
  US11/301,709
• Time in Patent Office: 1,646 Days
• Field of Search: 600/322, 600/323, 600/331, 600/336, 702/189, 702/191
• US Class Current: 600/336
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/7207 of noise induced by motion artifacts
• CPC Class Codes: A61N 1/36557 controlled by chemical substances in blood

Abstract

Methods and devices are provided for reducing motion artifacts when measuring blood oxygen saturation. A portion of the light having the first wavelength, a portion of light having the second wavelength and a portion of the light having the third wavelength are received. A first signal is produced based on the received portion of light having the first wavelength. Similarly, a second signal is produced based on the received portion of light having the second wavelength, and a third signal is produced based on the received portion of light having the third wavelength. A difference between the second signal and the first signal is determined, wherein the difference signal is first plethysmography signal. Similarly, a difference is determined between the third signal and the first signal to produce a second plethysmography signal. Blood oxygen saturation is then estimated using the first and second plethysmography signals.

Claims

1. A method for reducing effects of motion when measuring blood oxygen saturation, comprising the following steps of:

(a) transmitting light having a first wavelength, light having a second wavelength and light having a third wavelength through body tissue;

(b) receiving a portion of the light having the first wavelength, a portion of the light having the second wavelength and a portion of the light having the third wavelength;

(c) producing a first signal based on the received portion of light having the first wavelength, a second signal based on the received portion of light having the second wavelength, and a third signal based on the received portion of light having the third wavelength;

(d) determining a difference between the second signal and the first signal to produce a first plethysmography signal, and a difference between the third signal and the first signal to produce a second plethysmography signal;

adjusting a first ratio between an intensity of the light having the first wavelength and an intensity of the light having the second wavelength to thereby reduce motion artifacts associated with the first plethysmography signal; and

adjusting a second ratio between an intensity of the light having the first wavelength and an intensity of the light having the third wavelength to thereby reduce motion artifacts associated with the second plethysmography signal; and

(e) estimating blood oxygen saturation using the first and second plethysmography signals, wherein the estimating is performed using a processor.

2. The method of claim 1, wherein an intensity of the light having the first wavelength is kept constant while

the intensity of the light having the second wavelength is adjusted to substantially minimize the motion artifacts associated with the first plethysmography signal, and

the intensity of the light having the third wavelength is adjusted to substantially minimize motion artifacts associated with the second plethysmography signal.

3. The method of claim 1, wherein intensities of the light having the first wavelength, the light having the second wavelength, and the light having the third wavelengths are selected to substantially minimize motion artifacts in the first plethysmography signal and motion artifacts in the second plethysmography signal.

4. The method of claim 1, wherein step (a) comprises transmitting the light having the first wavelength, the light having the second wavelength and the light having the third wavelength through a patient'"'"'s finger, earlobe, foot or hand.

5. The method of claim 1, wherein step (a) comprises transmitting the light having the first wavelength, the light having the second wavelength and the light having the third wavelength from a light source implanted within a patient'"'"'s body.

6. The method of claim 1, wherein step (a) comprises transmitting the light having the first wavelength, the light having the second wavelength and the light having the third wavelength from a light source against or in close proximity to an epidermis of a patient.

7. The method of claim 1, wherein the first wavelength is about 805 nm, the second wavelength is about 660 nm and the third wavelength is about 905 nm.

8. The method of claim 1, further comprising the step of:

determining an average of the second signal and an average of the third signal; and

using the averages in step (e) when estimating the blood oxygen saturation.

9. The method of claim 1, further comprising the step of:

determining an average of the first signal, an average of the second signal, and an average of the third signal; and

using the averages in step (e) when estimating the blood oxygen saturation.

10. The method of claim 1, wherein step (e) includes:

determining a statistic using the first and second plethysmography signals, and

estimating the blood oxygen saturation based on the statistic.

11. A method for reducing effects of motion when measuring blood oxygen saturation, comprising the following steps of:

(a) transmitting light having a first wavelength, light having a second wavelength and light having a third wavelength through body tissue;

(b) receiving a portion of the light having the first wavelength, a portion of the light having the second wavelength and a portion of the light having the third wavelength;

(c) producing a first signal based on the received portion of light having the first wavelength, a second signal based on the received portion of light having the second wavelength, and a third signal based on the received portion of light having the third wavelength;

(d) determining a difference between the second signal and the first signal to produce a first plethysmography signal, and a difference between the third signal and the first signal to produce a second plethysmography signal;

adjusting a first ratio between a gain of the first signal and a gain of the second signal to thereby reduce motion artifacts associated with the first plethysmography signal; and

adjusting a second ratio between a gain of the first signal and a gain of the third signal to thereby reduce motion artifacts associated with the second plethysmography signal; and

(e) estimating blood oxygen saturation using the first and second plethysmography signals, wherein the estimating is performed using a processor.

12. The method of claim 11, wherein the gain of the first signal is kept constant while

the gain of the second signal is adjusted to substantially minimize motion artifacts associated with the first plethysmography signal, and

the gain of the third signal is adjusted to substantially minimize motion artifacts associated with the second plethysmography signal.

13. A device for measuring blood oxygen saturation, comprising:

a light source to transmit light having a first wavelength, light having a second wavelength and light having a third wavelength through body tissue;

a light detector to receive a portion of the light having the first wavelength, a portion of the light having the second wavelength, and a portion of the light having the third wavelength, and to produce a first signal, based on the received portion of light having the first wavelength, a second signal, based on the received portion of light having the second wavelength, and a third signal, based on the received portion of the light having the third wavelength;

a first comparator to subtract one of the first and second signals from the other to produce a first plethysmography signal;

a second comparator to subtract one of the first and third signals from the other to produce a second plethysmography signal;

means for adjusting one or more of the following ratios, to thereby reduce motion artifacts associated with at least one of the first and second plethysmography signals;

a ratio between an intensity of the light having the first wavelength and an intensity of the light having the second wavelength, a ratio between an intensity of the light having the first wavelength and an intensity of the light having the third wavelength, a ratio between a gain of the first signal and a gain of the second signal, and a ratio between a gain of the first signal and a gain of the third signal; and

means for estimating the blood oxygen saturation using the first and second plethysmography signals.

14. The device of claim 13, wherein the body tissue is within a human appendage of a patient.

15. The device of claim 13, wherein the body tissue is located below the epidermis of a patient.

16. The device of claim 13, wherein the first wavelength is about 805 nm, the second wavelength is about 660 nm and the third wavelength is about 905 nm.

17. The device of claim 13, wherein the light source comprises:

a first light emitting diode to produce the light having the first wavelength;

a second light emitting diode to produce the light having the second wavelength; and

a third light emitting diode to produce the light having the third wavelength.

18. The device of claim 13, wherein the light source comprises:

a first laser diode to produce the light having the first wavelength;

a second laser diode to produce the light having the second wavelength; and

a third laser diode to produce the light having the third wavelength.

19. The device of claim 13, wherein the light source comprises a lamp to produce a range of wavelengths including the light having the first wavelength, light having the second wavelength, and light having the third wavelength.

20. The device of claim 19, wherein the lamp comprises one of an incandescent lamp and a tungsten halogen lamp.

21. The device of claim 19, wherein the light detector comprises:

a first photodetector covered by a first optical filter that selectively passes light having the first wavelength;

a second photodetector covered by a second optical filter that selectively passes light having the second wavelength; and

a third photodetector covered by a third optical filter that selectively passes light having the third wavelength.

22. The device of claim 13, wherein the light detector comprises a first photodetector to receive the portion of the light having the first wavelength, a second photodetector to receive the portion of the light having the second wavelength, and a third photodetector to receive the portion of the light having the third wavelength.

23. The device of claim 13, wherein the light detector includes a photodetector to receive the first portion of light having the first wavelength, the second portion of light having the second wavelength and the third portion of light having the third wavelength.

24. The device of claim 23, wherein the light detector includes a demultiplexor to separate a first portion of a voltage signal representative of the first portion of light having the first wavelength from a second portion of the voltage signal representative of the second portion of light having the second wavelength and a third portion of the voltage signal representative of the third portion of light having the third wavelength.

25. The device of claim 24, wherein the light detector further includes:

a first bandpass filter to produce the first signal from the first portion of the voltage signal;

a second bandpass filter to produce the second signal from the second portion of the voltage signal; and

a third bandpass filter to produce the third signal from the third portion of the voltage signal.

26. The device of claim 13, wherein each comparator comprises a differential amplifier.

27. The device of claim 13, wherein the means for estimating blood oxygen saturation comprises a processor.

28. The device of claim 13, further comprising:

means for determining an average of the second signal; and

means for determining an average of the third signal;

wherein the means for estimating blood oxygen saturation also uses the averages when estimating blood oxygen saturation.

29. The device of claim 28, wherein each means for determining an average comprises a low pass filter.

30. The device of claim 13, further comprising:

means for determining an average of the first signal;

means for determining an average of the second signal; and

means for determining an average of the third signal;

wherein the means for estimating blood oxygen saturation also uses the averages when estimating blood oxygen saturation.

31. The device of claim 30, wherein each means for determining an average comprises a low pass filter.

32. The device of claim 13, wherein the light source and the light detector are configured, with respect to one another, in a transmission configuration.

33. The device of claim 13, wherein the light source and the light detector are configured, with respect to one another, in a reflection configuration.